Ashrafi K, Tahbaz A, Rahmati B
Iran J Parasitol. 2010 Sep;5(3):40-7.
Eosinophilia occurs in a wide variety of situations such as parasitic infections, allergic disorders, and malignancies. Most cases of eosinophilia of parasitic origin, especially those with a tissue migration life cycles consists of human infections by helminth parasites. The aim of present study was to determine the parasitic causes of eosinophilia in patients in a major endemic area of human fascioliasis in Gilan Province, northern part of Iran.
One hundred and fifty patients presenting with an elevated eosinophilia attending infectious disease clinics with or without clinical symptoms, were examined. After clinical history evaluation and physical examination, coprological examinations were performed using the formalin-ether and the Kato-Katz techniques for detection of Fasciola sp. and intestinal parasites.
Forty two percent of patients were infected with S. stercoralis, nine (6%) were found to be infected with Fasciola sp. while only a single patient (0.7%) were infected by Ttrichostrongylus sp.
Local clinicians in Gilan may consider eosinophilia as a suggestive indication for diagnosis of human fascioliasis, especially when microscopic stool and/or serological tests are negative. Based on the results, local physicians should consider S. stercoralis as the potential causes of eosinophilia in patients with elevated eosinophilia.
嗜酸性粒细胞增多症发生在多种情况下，如寄生虫感染、过敏性疾病和恶性肿瘤。大多数寄生虫源性嗜酸性粒细胞增多症病例，尤其是那些具有组织移行生命周期的病例，是由蠕虫寄生虫感染人类引起的。本研究的目的是确定伊朗北部吉兰省一个人类肝片吸虫病主要流行地区患者嗜酸性粒细胞增多症的寄生虫病因。
对150例有或无临床症状且嗜酸性粒细胞增多的传染病门诊患者进行检查。在评估临床病史和进行体格检查后，采用福尔马林-乙醚法和加藤-厚涂片法进行粪便检查，以检测肝片吸虫属和肠道寄生虫。
42%的患者感染了粪类圆线虫，9例（6%）被发现感染了肝片吸虫属，而只有1例患者（0.7%）感染了毛圆线虫属。
吉兰省的当地临床医生可将嗜酸性粒细胞增多症视为诊断人类肝片吸虫病的提示指标，尤其是在粪便显微镜检查和/或血清学检测为阴性时。根据研究结果，当地医生应将粪类圆线虫视为嗜酸性粒细胞增多患者嗜酸性粒细胞增多症的潜在病因。
