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肠易激综合征伴心境恶劣障碍患者中枢及外周促肾上腺皮质激素释放激素的研究进展。

Research Progress of Central and Peripheral Corticotropin-Releasing Hormone in Irritable Bowel Syndrome with Comorbid Dysthymic Disorders.

机构信息

College of Acupuncture and Massage, Anhui University of Chinese Medicine, Hefei, China.

College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, China.

出版信息

Gut Liver. 2024 May 15;18(3):391-403. doi: 10.5009/gnl220346. Epub 2023 Aug 8.

DOI:10.5009/gnl220346
PMID:37551453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11096901/
Abstract

Irritable bowel syndrome (IBS) is considered a stress disorder characterized by psychological and gastrointestinal dysfunction. IBS patients not only suffer from intestinal symptoms such as abdominal pain, diarrhea, or constipation but also, experience dysthymic disorders such as anxiety and depression. Studies have found that corticotropin-releasing hormone plays a key role in IBS with comorbid dysthymic disorders. Next, we will summarize the effects of corticotropin-releasing hormone from the central nervous system and periphery on IBS with comorbid dysthymic disorders and relevant treatments based on published literatures in recent years.

摘要

肠易激综合征（IBS）被认为是一种应激障碍，其特征为心理和胃肠道功能障碍。IBS 患者不仅有腹痛、腹泻或便秘等肠道症状，还伴有心境恶劣障碍，如焦虑和抑郁。研究发现，促肾上腺皮质激素释放激素在伴有心境恶劣障碍的 IBS 中起关键作用。接下来，我们将根据近年来发表的文献，从中枢神经系统和外周两个方面总结促肾上腺皮质激素释放激素对伴有心境恶劣障碍的 IBS 的影响及其相关治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e6/11096901/7c1371c1a779/gnl-18-3-391-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e6/11096901/7c1371c1a779/gnl-18-3-391-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9e6/11096901/7c1371c1a779/gnl-18-3-391-f1.jpg

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本文引用的文献

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[Meta analysis of acupuncture and moxibustion for anxiety and depression in irritable bowel syndrome].[针灸治疗肠易激综合征焦虑抑郁的Meta分析]
Zhen Ci Yan Jiu. 2022 Sep 25;47(9):821-9. doi: 10.13702/j.1000-0607.20210808.
2
Extraintestinal manifestations in irritable bowel syndrome: A systematic review.肠易激综合征的肠外表现：一项系统评价。
Therap Adv Gastroenterol. 2022 Aug 9;15:17562848221114558. doi: 10.1177/17562848221114558. eCollection 2022.
3
The potential impact of nutritional intake on symptoms severity in patients with comorbid migraine and irritable bowel syndrome.
营养摄入对伴有偏头痛和肠易激综合征的患者症状严重程度的潜在影响。
BMC Neurol. 2022 May 30;22(1):199. doi: 10.1186/s12883-022-02723-0.
4
Chronic stress increases DNA methylation of the GR promoter in the central nucleus of the amygdala of female rats.慢性应激增加了雌性大鼠杏仁中央核中 GR 启动子的 DNA 甲基化。
Neurogastroenterol Motil. 2022 Sep;34(9):e14377. doi: 10.1111/nmo.14377. Epub 2022 Apr 11.
5
Psychiatric Morbidity in Irritable Bowel Syndrome.肠易激综合征的精神病理学。
Mymensingh Med J. 2022 Apr;31(2):458-465.
6
Mast cell mediation of visceral sensation and permeability in irritable bowel syndrome.肠易激综合征内脏感觉和通透性的肥大细胞介导作用。
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