Sarakshi Netralaya, 19, Rajiv Nagar, Wardha Road, Nagpur, Maharashtra, 440025, India.
Lasers Med Sci. 2023 Aug 8;38(1):178. doi: 10.1007/s10103-023-03845-8.
The purpose of this study is to study the role of retro-mode (RM) in early detection and to compare it with other preexisting available modalities on multimodal imaging system in dry AMD. A prospective observational cross-sectional study was done between November 2020 and October 2021 which included 409 eyes of 207 patients. For study purpose, eyes were divided into 3 groups according to the size and number of the drusen, viz, group 1: No AMD, group 2: early AMD and group 3: intermediate AMD which was further divided into 2 subgroups, viz, subgroup A: eyes with drusen size 63-125 μm and subgroup B: eyes with drusen size 125-250 μm. Patients with active or treated wet AMD, scarred choroidal neovascular membrane (CNVM), other maculopathies, other retinopathies, high myopia, trauma and glaucoma were excluded from the study. In cases of No AMD and early AMD, a number of drusens detected on RM were statistically not significant compared to fundus autofluorescence (FAF) and color photo (CF), but in intermediate AMD cases, it was statistically significant. While the area involved by drusens calculated by RM was statistically significant compared to both other modalities. When all modalities were compared with enhanced depth imaging-optical coherence tomography (EDI-OCT) at the choroid and chorio-capillary (CC) level and vessel density (VD) on optical coherence tomography angiography (OCTA) at the choroid, capillaries, deep retinal and superficial retinal plexus level; it was only RM which was found to be in sync with these proven modalities in terms of pattern and trend. In the present scenario, RM is found to be a better diagnostic modality in detecting early and a greater number of drusens with area of involvement than other existing modalities. Though superior, as found in this study, this mode cannot replace other modalities at present but only acts as a complementary investigation in early detection of this disease.
本研究旨在探讨反向模式（RM）在早期检测中的作用，并将其与多模态成像系统中其他现有的可用模式进行比较，以研究干性年龄相关性黄斑变性（AMD）。这是一项在 2020 年 11 月至 2021 年 10 月间进行的前瞻性观察性横断面研究，共纳入了 207 名患者的 409 只眼。根据玻璃膜疣的大小和数量，研究将眼分为 3 组：第 1 组：无 AMD；第 2 组：早期 AMD；第 3 组：中期 AMD，其中又进一步分为 2 个亚组：A 组：玻璃膜疣大小为 63-125μm；B 组：玻璃膜疣大小为 125-250μm。患有活动性或治疗性湿性 AMD、瘢痕脉络膜新生血管膜（CNVM）、其他黄斑病变、其他视网膜病变、高度近视、外伤和青光眼的患者被排除在研究之外。在无 AMD 和早期 AMD 中，RM 检测到的玻璃膜疣数量与自发荧光（FAF）和彩色照片（CF）相比没有统计学意义，但在中期 AMD 中，两者之间有统计学意义。而 RM 计算的玻璃膜疣受累面积与其他两种模式相比具有统计学意义。当将所有模式与增强深度成像-光相干断层扫描（EDI-OCT）在脉络膜和脉络膜毛细血管（CC）水平以及光学相干断层扫描血管造影（OCTA）在脉络膜、毛细血管、深层视网膜和浅层视网膜丛水平的血管密度（VD）进行比较时；只有 RM 在模式和趋势上与这些已证实的模式相吻合。在目前的情况下，RM 被发现是一种更好的诊断模式，能够比其他现有的模式更早地检测到更多的玻璃膜疣，并检测到其受累面积。尽管在本研究中发现 RM 优于其他模式，但目前它不能替代其他模式，而只能作为该疾病早期检测的补充手段。
