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头颈部肿瘤和组织中富含酪氨酸的晶体。

Tyrosine-rich crystalloids in neoplasms and tissues of the head and neck.

作者信息

Harris B R, Shipkey F

出版信息

Arch Pathol Lab Med. 1986 Aug;110(8):709-12.

PMID:3755326
Abstract

Tyrosine-rich crystalloids were identified in three benign mixed tumors of the parotid gland, one terminal duct adenocarcinoma of a minor salivary gland, and the fibrous connective tissue of two laryngectomy specimens. Light and electron microscopic studies showed the crystalloids to be composed of irregular deposits of amorphous electron-dense material. In the salivary gland tumors this material was commonly associated with interstitial collagen and was found in greatest abundance near myoepithelial cells. This proximity suggests that the tyrosine-rich crystalloids result from the precipitation on stromal collagen of products secreted by neoplastic myoepithelial cells.

摘要

在三例腮腺良性混合瘤、一例小涎腺终末导管腺癌以及两份喉切除标本的纤维结缔组织中发现了富含酪氨酸的晶体。光镜和电镜研究显示,这些晶体由无定形电子致密物质的不规则沉积物组成。在涎腺肿瘤中,这种物质通常与间质胶原相关,且在肌上皮细胞附近含量最高。这种 proximity 表明,富含酪氨酸的晶体是由肿瘤性肌上皮细胞分泌的产物在基质胶原上沉淀形成的。 (注:此处“proximity”疑为“相近性、接近”之意,原文表述稍显奇怪,可能存在信息不完整,但按照要求进行了翻译)

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