Clinical Outcomes Solutions, 1820 E River Rd, Ste 220, Tucson, AZ, 85718, USA.
Clinical Outcomes Solutions, Chicago, IL, USA.
Health Qual Life Outcomes. 2023 Aug 8;21(1):83. doi: 10.1186/s12955-023-02162-6.
Psoriasis is a common autoimmune dermatologic condition which has a pronounced negative impact on patient quality of life and disease burden. Currently, there are a number of treatments available for psoriasis, with differences in efficacy, mechanism of action, mode of administration, adverse effects, and tolerability. However, a reliable, validated patient-reported instrument to address patient expectations and of psoriasis treatment has not been developed. This project was undertaken with the aim of developing a fit-for-purpose self-reported instrument to inform patient expectations and preferences of psoriasis treatments.
Two studies, both utilizing qualitative and quantitative methods, were conducted in patients within the entire spectrum of psoriasis severity. In Study 1, a group concept mapping (GCM) exercise was conducted with dermatologists and moderate-to-severe psoriasis patients to identify concepts important in the treatment of psoriasis. In Study 2, a preliminary Treatment Acceptability Questionnaire (TAQ) was developed using GCM-derived concepts from Studies 1 and 2, followed by cognitive debriefing (CD) telephone interviews of the preliminary TAQ. In Study 2, another GCM exercise was conducted with mild and newly diagnosed psoriasis patients. Psychometric analyses were performed on the TAQ to evaluate validity and reliability.
The Study 1 GCM exercise generated 43 concepts from moderate-to-severe psoriasis patients (n = 20) and dermatologists (n = 10). In Study 2, 37 GCM concepts were generated from mild and newly diagnosed psoriasis patients (n = 20). From the 2 GCM exercises, 28 concepts were selected to form the preliminary TAQ; CD interviews indicated strong understanding and relevance of TAQ items among patients with disease ranging from mild to severe. The final TAQ consisted of 20 items; psychometric analysis demonstrated strong validity and reliability of the TAQ.
The TAQ is a novel psychometrically validated patient-reported instrument to inform healthcare providers of patients' expectations of and preferences for treatment of their psoriasis and can help in shared decision making between patients and physicians.
银屑病是一种常见的自身免疫性皮肤病，对患者的生活质量和疾病负担有明显的负面影响。目前，有许多治疗银屑病的方法，其疗效、作用机制、给药方式、不良反应和耐受性存在差异。然而，尚未开发出一种可靠、经过验证的患者报告工具来评估患者对银屑病治疗的期望。本项目旨在开发一种适合的自我报告工具，以了解患者对银屑病治疗的期望和偏好。
两项研究均采用定性和定量方法，在整个银屑病严重程度范围内的患者中进行。在研究 1 中，对皮肤科医生和中重度银屑病患者进行了小组概念映射（GCM）练习，以确定治疗银屑病的重要概念。在研究 2 中，使用来自研究 1 和 2 的 GCM 衍生概念开发了初步的治疗可接受性问卷（TAQ），随后对初步 TAQ 进行了认知访谈。在研究 2 中，还对轻度和新诊断的银屑病患者进行了另一次 GCM 练习。对 TAQ 进行了心理测量学分析，以评估其有效性和可靠性。
研究 1 的 GCM 练习从中重度银屑病患者（n=20）和皮肤科医生（n=10）中生成了 43 个概念。在研究 2 中，20 名轻度和新诊断的银屑病患者生成了 37 个 GCM 概念。从这 2 项 GCM 练习中，选择了 28 个概念来形成初步的 TAQ；认知访谈表明，疾病从轻度到重度的患者对 TAQ 项目有很强的理解和相关性。最终的 TAQ 由 20 个项目组成；心理测量分析表明 TAQ 具有很强的有效性和可靠性。
TAQ 是一种新颖的心理测量验证患者报告工具，可向医疗保健提供者提供患者对其银屑病治疗的期望和偏好，并有助于患者和医生之间的共同决策。
