Beal M F, Chattha G K, Martin J B
Brain Res. 1986 Jul 9;377(2):240-5. doi: 10.1016/0006-8993(86)90864-4.
Somatostatin-like immunoreactivity (SLI) and neuropeptide Y-like immunoreactivity (NPYLI) were detected using specific radioimmunoassays in extracts from rat brain. Since we have previously found a topographic distribution of SLI in rat striatum the distribution of NPYLI was examined in the same regions. NPYLI showed an identical distribution to SLI in rat striatum and levels were significantly correlated (r = 0.93, P less than 0.01). Concentrations of both neuropeptides were consistently highest in ventromedial striatum and nucleus accumbens while they were lowest in dorsolateral striatum. These findings provide further evidence of neurochemical heterogeneity in the striatum. Concentrations of NPYLI and SLI were also significantly correlated in cerebral cortex (r = 0.99, P less than 0.01). Concentrations of NPYLI were generally higher than SLI and showed a similar predilection for limbic system nuclei. The present findings support the concept that somatostatin and neuropeptide Y may be co-localized in both striatal and cortical neurons.
采用特异性放射免疫分析法在大鼠脑提取物中检测生长抑素样免疫反应性（SLI）和神经肽Y样免疫反应性（NPYLI）。由于我们之前已发现大鼠纹状体中SLI的拓扑分布，因此在相同区域检测了NPYLI的分布。NPYLI在大鼠纹状体中的分布与SLI相同，且水平显著相关（r = 0.93，P < 0.01）。两种神经肽的浓度在腹内侧纹状体和伏隔核中始终最高，而在背外侧纹状体中最低。这些发现为纹状体中神经化学异质性提供了进一步证据。NPYLI和SLI的浓度在大脑皮层中也显著相关（r = 0.99，P < 0.01）。NPYLI的浓度通常高于SLI，并且对边缘系统核团表现出类似的偏好。目前的发现支持生长抑素和神经肽Y可能在纹状体和皮层神经元中共同定位的概念。
