Beal M F, Mazurek M F, McKee M A
Department of Neurology, Massachusetts General Hospital, Boston 02114.
Neurosci Lett. 1987 Aug 18;79(1-2):201-6. doi: 10.1016/0304-3940(87)90697-5.
Somatostatin-like immunoreactivity (SLI) and neuropeptide Y-like immunoreactivity (NPYLI) were measured in subdissections of both normal and Alzheimer's disease (AD) striatum at 5 coronal levels. Concentrations of both neuropeptides were relatively homogeneously distributed in the coronal and anterior-posterior planes except for a trend towards increased concentrations in the tail of the caudate and the posterior putamen. The nucleus accumbens showed 2-3-fold higher concentrations of both SLI and NPYLI than the rest of the striatum. There were no significant differences between control and AD brains. The high concentrations of SLI and NPYLI in the nucleus accumbens suggest that this region may receive somatostatin-neuropeptide Y afferents and that somatostatin and neuropeptide Y may play a role in the modulation of motor activity.
在5个冠状层面上，对正常和阿尔茨海默病（AD）纹状体的亚解剖结构进行了生长抑素样免疫反应性（SLI）和神经肽Y样免疫反应性（NPYLI）的测量。除了尾状核尾部和壳核后部浓度有增加趋势外，两种神经肽的浓度在冠状面和前后平面上相对均匀分布。伏隔核中SLI和NPYLI的浓度比纹状体其他部位高2至3倍。对照组和AD脑之间无显著差异。伏隔核中SLI和NPYLI的高浓度表明该区域可能接受生长抑素-神经肽Y传入纤维，并且生长抑素和神经肽Y可能在运动活动的调节中发挥作用。
