Pulmonary surfactant activity after severe steam inhalation injury in rabbits.

Lung water content, Pao2, surface tension (in terms of hysteresis) and lecithin content of both bronchial irrigation fluid and lung homogenates were determined after severe steam inhalation injury in rabbits. At the time of a decrease in Pao2 and an increase in lung water content there was a moderate fall in pulmonary surfactant activity; as shown by a progressive decrease in the area of the hysteresis loop and a decrease of the lecithin content in both bronchial irrigation fluid and lung homogenate. It is proposed that a fall in pulmonary surfactant activity plays an important role in the pathogenesis of pulmonary oedema after inhalation injury. Successive determinations of lecithin content and/or surface tension of bronchial irrigation fluid are recommended as early diagnostic and prognostic aids in severe inhalation injury.