Department of Pediatrics, Beijing Jishuitan Hospital, Beijing, China.
Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Obesity (Silver Spring). 2023 Sep;31(9):2365-2374. doi: 10.1002/oby.23847. Epub 2023 Aug 8.
The aim of this study was to investigate when the association between childhood obesity and adult cardiometabolic disorders starts to be operative.
The study cohort included 811 participants who had data on blood pressure, lipid profile, fasting blood glucose, fasting insulin, or alanine aminotransferase in adulthood and had at least one measurement of BMI in childhood.
Childhood BMI z score was significantly associated with increased risks of ≥1 cardiometabolic disorders, ≥2 cardiometabolic disorders, and elevated blood pressure in adulthood for age groups of 6 to 9 years, 10 to 12 years, 13 to 15 years, and 16 to 18 years, after adjustment for covariates. For low high-density lipoprotein cholesterol, significant associations were observed for age groups of 10 to 12 years, 13 to 15 years, and 16 to 18 years. For elevated triglyceride and elevated alanine aminotransferase, significant associations were observed for age groups of 13 to 15 years and 16 to 18 years. For insulin resistance, significant associations were observed for age groups of 10 to 12 years and 16 to 18 years. For elevated total cholesterol, elevated low-density lipoprotein cholesterol, or elevated fasting blood glucose, no association was observed in any age group.
The association between childhood BMI and adult cardiometabolic disorders begins to be operative from early life. These results support universal screening of childhood obesity starting at an early age.
本研究旨在探讨儿童肥胖与成人代谢综合征相关疾病之间的关联何时开始起作用。
研究队列纳入了 811 名参与者，这些参与者在成年期有血压、血脂谱、空腹血糖、空腹胰岛素或丙氨酸氨基转移酶的数据，并且在儿童时期至少有一次 BMI 的测量值。
儿童 BMI z 评分与成年后患≥1 种代谢综合征相关疾病、≥2 种代谢综合征相关疾病和血压升高显著相关，在 6-9 岁、10-12 岁、13-15 岁和 16-18 岁年龄组，在校正协变量后。对于低高密度脂蛋白胆固醇，在 10-12 岁、13-15 岁和 16-18 岁年龄组观察到显著关联。对于甘油三酯升高和丙氨酸氨基转移酶升高，在 13-15 岁和 16-18 岁年龄组观察到显著关联。对于胰岛素抵抗，在 10-12 岁和 16-18 岁年龄组观察到显著关联。对于总胆固醇升高、低密度脂蛋白胆固醇升高或空腹血糖升高，在任何年龄组均未观察到关联。
儿童 BMI 与成人代谢综合征相关疾病之间的关联从生命早期开始起作用。这些结果支持从早期开始对儿童肥胖进行普遍筛查。
