Department of Ophthalmology, Manisa Celal Bayar University, Medical Faculty, Manisa, Turkiye.
J Coll Physicians Surg Pak. 2023 Aug;33(8):932-935. doi: 10.29271/jcpsp.2023.08.932.
To evaluate the histopathological results of conjunctival masses suspected to be malignant based on biomicroscopic examination.
Observational study. Place and Duration of the Study: Department of Ophthalmology, Celal Bayar University, Hafsa Sultan Hospital, Manisa, Turkiye, from November 2013 to February 2021.
Patients who underwent excision for the diagnosis and treatment of conjunctival surface masses with clinical suspicion of malignancy were evaluated retrospectively. The masses were categorised as benign, premalignant, and malignant lesions according to the histopathological results. The distribution of conjunctival masses was analysed according to patients' gender and age groups.
The study included 98 conjunctival masses in 98 patients (57.1% men, mean age 48.6±21.85 years). On pathological examination, 63 of the masses were found to be benign (64.3%), 22 were premalignant (22.4%), and 13 were malignant (13.3%). The most common benign lesion was nevus (n=21, 21.4%). All detected premalignant lesions were conjunctival intraepithelial neoplasms (CIN), detected in 22 patients (22.4%). Of these, 13 patients (13.3%) had carcinoma in situ (CIN III). Thirteen (13.3%) of the masses were malignant, the most common being squamous cell carcinoma (n=10, 10.2%). The frequency of premalignant and malignant lesions increased with age (p<0.001). There was no statistical relationship between malignancy and gender (p=0.619).
Most conjunctival masses in this series were benign, with nevi being the most common. The most common premalignant and malignant lesions were intraepithelial neoplasia and squamous cell carcinoma, respectively. Malignant conjunctival lesions were more common in older patients.
Conjunctival nevus, Conjunctival intraepithelial neoplasia, Squamous cell carcinoma.
评估基于生物显微镜检查怀疑恶性的结膜肿块的组织病理学结果。
观察性研究。地点和研究时间：土耳其马尼萨 Celal Bayar 大学 Hafsa Sultan 医院眼科，2013 年 11 月至 2021 年 2 月。
回顾性评估了因临床怀疑恶性而接受切除诊断和治疗结膜表面肿块的患者。根据组织病理学结果，将肿块分为良性、癌前病变和恶性病变。根据患者的性别和年龄组分析结膜肿块的分布。
本研究共纳入 98 例 98 名患者（57.1%为男性，平均年龄 48.6±21.85 岁）的 98 例结膜肿块。病理检查发现 63 例为良性（64.3%），22 例为癌前病变（22.4%），13 例为恶性（13.3%）。最常见的良性病变为痣（n=21，21.4%）。所有检测到的癌前病变均为结膜上皮内瘤变（CIN），共 22 例（22.4%）。其中，13 例（13.3%）为原位癌（CIN III）。13 例（13.3%）为恶性，最常见的是鳞状细胞癌（n=10，10.2%）。癌前病变和恶性病变的发生率随年龄增长而增加（p<0.001）。性别与恶性之间无统计学关系（p=0.619）。
本系列中大多数结膜肿块为良性，痣最常见。最常见的癌前病变和恶性病变分别为上皮内肿瘤和鳞状细胞癌。老年患者中恶性结膜病变更为常见。
结膜痣、结膜上皮内瘤变、鳞状细胞癌。
