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Novel discovery of PDPN-positive CAFs contributing to tumor-associated lymphangiogenesis through mesenchymal to lymphatic endothelial transition in intrahepatic cholangiocarcinoma.

作者信息

Sha Meng, Shen Chuan, Jeong Seogsong, Xu Ning, Chen Chen, Hang Hua-Lian, Tong Ying, Cao Jie

机构信息

Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Department of Biomedical Informatics, CHA University School of Medicine, CHA University, Seongnam 13488, Republic of Korea.

出版信息

Genes Dis. 2023 Mar 28;10(6):2226-2228. doi: 10.1016/j.gendis.2023.02.023. eCollection 2023 Nov.

DOI:10.1016/j.gendis.2023.02.023
PMID:37554192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10405000/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa0/10405000/9f24d331779b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa0/10405000/9f24d331779b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aa0/10405000/9f24d331779b/gr1.jpg

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1
Novel discovery of PDPN-positive CAFs contributing to tumor-associated lymphangiogenesis through mesenchymal to lymphatic endothelial transition in intrahepatic cholangiocarcinoma.通过肝内胆管癌中间充质向淋巴管内皮细胞转变促进肿瘤相关淋巴管生成的PDPN阳性癌症相关成纤维细胞的新发现。
Genes Dis. 2023 Mar 28;10(6):2226-2228. doi: 10.1016/j.gendis.2023.02.023. eCollection 2023 Nov.
2
High-mobility group box 1 expression and lymph node metastasis in intrahepatic cholangiocarcinoma.高迁移率族蛋白盒1在肝内胆管癌中的表达与淋巴结转移
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3
Lymphatic spread is related to VEGF-C expression and D2-40-positive myofibroblasts in intrahepatic cholangiocarcinoma.肝内胆管癌的淋巴转移与血管内皮生长因子C（VEGF-C）表达及D2-40阳性肌成纤维细胞有关。
Mod Pathol. 2008 Mar;21(3):256-64. doi: 10.1038/modpathol.3800985. Epub 2008 Jan 11.
4
Thrombospondin 1 and 2 along with PEDF inhibit angiogenesis and promote lymphangiogenesis in intrahepatic cholangiocarcinoma.血小板反应蛋白 1 和 2 以及 PEDF 抑制肝内胆管癌的血管生成并促进淋巴管生成。
J Hepatol. 2021 Dec;75(6):1377-1386. doi: 10.1016/j.jhep.2021.07.016. Epub 2021 Jul 28.
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Expression of VEGFR-3 in intrahepatic cholangiocarcinoma correlates with unfavorable prognosis through lymphangiogenesis.VEGFR-3 在肝内胆管癌中的表达通过淋巴管生成与不良预后相关。
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Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma.肿瘤相关淋巴管生成预测肝内胆管癌不良预后。
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Podoplanin is a component of extracellular vesicles that reprograms cell-derived exosomal proteins and modulates lymphatic vessel formation.血小板源性生长因子受体是细胞外囊泡的一个组成部分，可对细胞来源的外泌体蛋白进行重编程，并调节淋巴管的形成。
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Podoplanin, α-smooth muscle actin or S100A4 expressing cancer-associated fibroblasts are associated with different prognosis in colorectal cancers.在结直肠癌中，表达 podoplanin、α-平滑肌肌动蛋白或 S100A4 的癌相关成纤维细胞与不同的预后相关。
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引用本文的文献

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Mechanisms of Cancer Cell Lymphatic Endothelialization in Tumor Lymphangiogenesis and Metastasis: A Comprehensive Review.肿瘤淋巴管生成和转移中癌细胞淋巴管内皮化的机制：综述
J Inflamm Res. 2025 Aug 9;18:10741-10750. doi: 10.2147/JIR.S535351. eCollection 2025.

本文引用的文献

1
Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma.肿瘤相关淋巴管生成预测肝内胆管癌不良预后。
BMC Cancer. 2019 Mar 8;19(1):208. doi: 10.1186/s12885-019-5420-z.
2
Podoplanin expression in cancer-associated fibroblasts predicts unfavourable prognosis in patients with pathological stage IA lung adenocarcinoma.肿瘤相关成纤维细胞中 podoplanin 的表达预示着病理分期为 IA 期肺腺癌患者的预后不良。
Histopathology. 2018 Feb;72(3):490-499. doi: 10.1111/his.13390. Epub 2017 Nov 27.
3
Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors.
癌症干细胞通过激活乳腺肿瘤中的 Hedgehog 信号通路调节癌症相关成纤维细胞。
Cancer Res. 2017 Apr 15;77(8):2134-2147. doi: 10.1158/0008-5472.CAN-15-3490. Epub 2017 Feb 15.
4
Podoplanin-expressing cancer-associated fibroblasts lead and enhance the local invasion of cancer cells in lung adenocarcinoma.表达 Podoplanin 的癌相关成纤维细胞促进并增强肺腺癌中癌细胞的局部浸润。
Int J Cancer. 2015 Aug 15;137(4):784-96. doi: 10.1002/ijc.29464. Epub 2015 Feb 20.
5
Epithelial-mesenchymal transition in human cancer: comprehensive reprogramming of metabolism, epigenetics, and differentiation.人类癌症中的上皮-间充质转化：代谢、表观遗传学和分化的全面重编程。
Pharmacol Ther. 2015 Jun;150:33-46. doi: 10.1016/j.pharmthera.2015.01.004. Epub 2015 Jan 13.