Ouanes Yassine, Chaker Kays, Nouira Yassine
Department of Urology, LA RABTA Hospital, University of TUNIS EL MANAR, Tunis, Tunisia.
Ann Med Surg (Lond). 2023 Jun 7;85(8):3833-3837. doi: 10.1097/MS9.0000000000000862. eCollection 2023 Aug.
The prognostic significance of the platelet-lymphocyte ratio (PLR) in nonmetastatic renal cell carcinoma (RCC) is controversial, although it has been established as a prognostic factor in several cancers.
The objective of our study was to evaluate the prognostic significance of the PLR in patients with nonmetastatic RCC.
The authors performed a retrospective analysis of patients with nonmetastatic RCC who were operated between 2004 and 2020. Five years recurrence-free survival and metastasis-free survival were calculated. The prognostic significance of the preoperative PLR was assessed. The Kaplan-Meier method was utilized to graphically display survivor functions. Univariate and multivariate Cox's proportional hazards regression models were utilized to analyze the association between PLR and oncological outcomes. Differences were considered significant if <0.05.
Two hundred and two patients were included. The mean follow-up was 56.8±3 months. Patients with a higher PLR had larger tumors (=0.02), higher ASA score (=0.001), symptomatic forms (=0.01), and more frequent tumor necrosis (=0.02). Recurrence-free survival and metastasis-free survival rates were significantly lower in patients with high PLR than in those with low ratios (each <0.005). Multivariate analysis identified PLR as an independent predictor of recurrence-free survival (=0.002) and metastasis-free survival (<0.001).
A higher PLR was associated with aggressive renal cancer. In addition, the PLR was a significant prognostic factor for both recurrence-free survival and metastasis-free survival in patients with nonmetastatic RCC.
血小板淋巴细胞比率（PLR）在非转移性肾细胞癌（RCC）中的预后意义存在争议，尽管它已被确立为多种癌症的预后因素。
我们研究的目的是评估PLR在非转移性RCC患者中的预后意义。
作者对2004年至2020年间接受手术的非转移性RCC患者进行了回顾性分析。计算了5年无复发生存率和无转移生存率。评估了术前PLR的预后意义。采用Kaplan-Meier方法以图形方式展示生存函数。使用单变量和多变量Cox比例风险回归模型分析PLR与肿瘤学结局之间的关联。如果<0.05，则认为差异具有统计学意义。
纳入202例患者。平均随访时间为56.8±3个月。PLR较高的患者肿瘤较大（=0.02）、ASA评分较高（=0.001）、有症状表现（=0.01）且肿瘤坏死更频繁（=0.02）。高PLR患者的无复发生存率和无转移生存率显著低于低PLR患者（均<0.005）。多变量分析确定PLR是无复发生存（=0.002）和无转移生存（<0.001）的独立预测因素。
较高的PLR与侵袭性肾癌相关。此外，PLR是非转移性RCC患者无复发生存和无转移生存的重要预后因素。
