Sumitomo Chiho, Iwata Yohei, Arima Masaru, Sugiura Kazumitsu
Department of Dermatology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan.
Fujita Med J. 2023 Aug;9(3):236-239. doi: 10.20407/fmj.2022-030. Epub 2023 May 9.
Extramammary Paget's disease (EMPD) is a neoplastic skin disease of unknown etiology. EMPD is frequently associated with forkhead box A1 (FOXA1) expression, which correlates with the expression of estrogen receptor alpha (ER). FOXA1 regulates the transcriptional activity of ER and may function cooperatively in the tumorigenesis of breast cancer.
We performed immunohistochemical staining for FOXA1 and ER using tissue samples from 16 patients with EMPD.
The nuclei of Paget cells isolated from each of the 16 patients with EMPD (100%) were strongly FOXA1-positive, and the FOXA1 staining intensity was similar across all samples. ER staining was detected in the nuclei of Paget cells originating from seven patients with EMPD (44%), and the ER staining intensity varied between these patients.
In the present study, we confirmed that EMPD was frequently associated with FOXA1 expression. However, ER expression varied between patients and did not always coincide with FOXA1 expression. No clear relationship was observed between ER expression, the intensity of ER staining, or EMPD metastasis and prognosis. However, the results indicate that hormone-dependent cancer therapy may be effective in patients with ER-positive EMPD.
乳腺外佩吉特病（EMPD）是一种病因不明的肿瘤性皮肤病。EMPD常与叉头框A1（FOXA1）表达相关，而FOXA1表达与雌激素受体α（ER）表达相关。FOXA1调节ER的转录活性，可能在乳腺癌的肿瘤发生中协同发挥作用。
我们使用16例EMPD患者的组织样本对FOXA1和ER进行免疫组织化学染色。
从16例EMPD患者中分离出的佩吉特细胞的细胞核（100%）均为FOXA1强阳性，且所有样本的FOXA1染色强度相似。在7例EMPD患者（44%）的佩吉特细胞核中检测到ER染色，且这些患者之间的ER染色强度有所不同。
在本研究中，我们证实EMPD常与FOXA1表达相关。然而，患者之间的ER表达存在差异，且并不总是与FOXA1表达一致。未观察到ER表达、ER染色强度或EMPD转移与预后之间存在明确关系。然而，结果表明激素依赖性癌症治疗可能对ER阳性的EMPD患者有效。
