Nakanaga Hiroshi, Kinoshita Takeshi, Fujii Hiromi, Nagashima Kohei, Tabata Minoru
Department of Cardiovascular Surgery, Cardiovascular Center, Toranomon Hospital, Tokyo, Japan.
Department of Cardiovascular Surgery, Juntendo University Hospital, Tokyo, Japan.
JTCVS Tech. 2023 Apr 25;20:99-104. doi: 10.1016/j.xjtc.2023.04.008. eCollection 2023 Aug.
In minimally invasive cardiac surgery, it can be difficult at times to maintain adequate oxygenation with single-lung ventilation after weaning from cardiopulmonary bypass (CPB), and intermittent double-lung ventilation is required during hemostasis. Venovenous extracorporeal membrane oxygenation (VV-ECMO) after weaning from CPB eliminates the necessity of overinflation of the left lung and intermittent double-lung ventilation and enables secure and fast hemostasis. We investigated the effectiveness and safety of temporary VV-ECMO in MICS.
Between May 2018 and March 2021, 149 patients underwent temporary VV-ECMO during minimally invasive cardiac surgery in our institutions. After weaning from CPB, the arterial circuit was reconnected to the right internal jugular venous cannula, the femoral venous cannula was pulled down by 20 cm, and VV-ECMO was established using the CPB machine and cannulas. After starting VV-ECMO, we administered protamine and performed hemostasis. Operative data and outcomes were retrospectively reviewed.
The mean VV-ECMO time and flow were 26 ± 13 minutes and 2.38 ± 0.40 L/m, respectively. There was no thrombus in the CPB circuit, including the oxygenator. The trans-oxygenator pressure gradient index at the end of VV-ECMO significantly correlated with that at the start of VV-ECMO ( = 0.88; 95% CI, 0.79-0.94; = .01). The 30-day mortality rate was 2.0%. The incidences of unilateral pulmonary edema, prolonged ventilation, and re-exploration for bleeding were 2.7%, 5.4%, and 2.0%, respectively.
Temporary VV-ECMO is safe and useful to maintain single-lung ventilation without overinflation after weaning from CPB for secure and fast hemostasis in minimally invasive cardiac surgery. No thrombotic event was found during temporary VV-ECMO without heparinization.
在微创心脏手术中,体外循环(CPB)撤机后有时难以通过单肺通气维持充足的氧合,止血过程中需要间歇性双肺通气。CPB撤机后采用静脉-静脉体外膜肺氧合(VV-ECMO)可避免左肺过度膨胀和间歇性双肺通气的必要性,并能实现安全、快速止血。我们研究了临时VV-ECMO在微创心脏手术中的有效性和安全性。
2018年5月至2021年3月期间,我们机构的149例患者在微创心脏手术中接受了临时VV-ECMO。CPB撤机后,将动脉管路重新连接至右颈内静脉插管,将股静脉插管向下拉20 cm,并使用CPB机和插管建立VV-ECMO。启动VV-ECMO后,我们给予鱼精蛋白并进行止血。对手术数据和结果进行回顾性分析。
平均VV-ECMO时间和流量分别为26±13分钟和2.38±0.40 L/m。包括氧合器在内的CPB管路中未发现血栓。VV-ECMO结束时的跨氧合器压力梯度指数与VV-ECMO开始时显著相关(r = 0.88;95%CI,0.79 - 0.94;P = 0.01)。30天死亡率为2.0%。单侧肺水肿、通气时间延长和再次开胸止血的发生率分别为2.7%、5.4%和2.0%。
临时VV-ECMO安全且有助于在微创心脏手术中CPB撤机后维持单肺通气而无需过度膨胀,以实现安全、快速止血。在未进行肝素化的临时VV-ECMO期间未发现血栓形成事件。