Ji Cheng-Long, Zhai Xinyi, Fang Qing-Yun, Zhu Chengjian, Han Jie, Xie Jin
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Green Catalysis Center, College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China.
Chem Soc Rev. 2023 Aug 29;52(17):6120-6138. doi: 10.1039/d3cs00110e.
In recent years, the activation of unactivated alkyl chlorides through light-induced processes has emerged as a promising field in radical chemistry, and has led to new transformations in organic synthesis. Direct utilization of alkyl chlorides as C(sp)-hybridized electrophiles enables the facile construction of carbon-carbon and carbon-heteroatom bonds. Furthermore, recent studies in medicinal chemistry indicate that their presence is associated with high levels of success in clinical trials. This review summarizes the recent advances in the photoinduced activation of unactivated alkyl chlorides and discusses the mechanistic aspects underlying these reactions. We anticipate that this review will serve as a valuable resource for researchers in the field of unactivated chemical bond functionalization, and inspire considerable developments in organic chemistry, drug synthesis, materials science and other related disciplines.
近年来，通过光诱导过程实现未活化烷基氯的活化已成为自由基化学中一个很有前景的领域，并在有机合成中带来了新的转化。直接将烷基氯用作C(sp)杂化亲电试剂能够轻松构建碳-碳键和碳-杂原子键。此外，药物化学领域的最新研究表明，它们的存在与临床试验的高成功率相关。本综述总结了未活化烷基氯光诱导活化的最新进展，并讨论了这些反应背后的机理。我们预计，本综述将为未活化化学键功能化领域的研究人员提供宝贵资源，并激发有机化学、药物合成、材料科学及其他相关学科的重大发展。
