Influence of H-2 haplotypes on poly IC induction of xanthine oxidase and poly IC induced decreases in P-450 mediated enzyme activities.

Polyriboinosinic-polyribocytidylic acid (poly IC), a potent interferon inducer, induced xanthine oxidase 24 hours after treatment with 5 mg/kg ip to different degrees among four H-2 congenic mice (P less than 0.05): B10 (H-2b: 236 +/- 27% of the control value) greater than B10.RIII (H-2r: 171 +/- 29%) = B10.F (H-2n: 161 +/- 12%) greater than B10.BR (H-2k: 136 +/- 15%). Aryl hydrocarbon hydroxylase (AHH) activity showed an inverse correlation with inducibility of xanthine oxidase (r = -0.71, P less than 0.01). However, there were no significant changes in activities of heme pool associated enzymes, such as catalase, tryptophan pyrrolase and d-aminolevulinic acid synthase in these mice. H-2 haplotype seems to have an influence on poly IC induction of xanthine oxidase thereby causing a decrease in AHH.