用聚肌胞苷酸治疗可增强小鼠和大鼠的脂质过氧化作用及黄嘌呤氧化酶活性，并降低肝脏中P-450的含量和活性。

Treatment with poly I.C. enhances lipid peroxidation and the activity of xanthine oxidase, and decreases hepatic P-450 content and activities in mice and rats.

作者信息

Koizumi A, Walford R L, Imamura T

出版信息

Biochem Biophys Res Commun. 1986 Jan 29;134(2):632-7. doi: 10.1016/s0006-291x(86)80466-1.

Abstract

Treatment of mice and rats with polyriboinosinic acid-polyribocytidylic acid (poly I.C., 5 mg/kg i.p.), a potent interferon inducer, decreased hepatic cytochrome P-450 system content and activities without influencing P-450-independent xenobiotic metabolizing enzymes. Treatment with poly I.C. decreased the content of P-450 by 28% in mice (P less than 0.05) and 30% in rats (P less than 0.05) but did not alter the activity of cytochrome c reductase. With treatment of poly I.C., the activity of XO increased 87% in mice (P less than 0.01) and 30% in rats (P less than 0.01). Lipid peroxidation was enhanced by 82% in mice (P less than 0.01) and 95% in rats (P less than 0.05). These results raise the possibility that a part of the depression of P-450 system content and activities by poly I.C. might be caused by enhanced lipid peroxidation associated with increased activity of XO.

摘要

用聚肌苷酸-聚胞苷酸（聚肌胞苷酸，5毫克/千克腹腔注射）处理小鼠和大鼠，聚肌胞苷酸是一种强效干扰素诱导剂，它降低了肝脏细胞色素P-450系统的含量和活性，而不影响不依赖P-450的外源性物质代谢酶。用聚肌胞苷酸处理使小鼠体内P-450的含量降低了28%（P<0.05），大鼠降低了30%（P<0.05），但未改变细胞色素c还原酶的活性。用聚肌胞苷酸处理后，小鼠体内XO的活性增加了87%（P<0.01），大鼠增加了30%（P<0.01）。小鼠体内脂质过氧化增强了82%（P<0.01），大鼠增强了95%（P<0.05）。这些结果提示，聚肌胞苷酸导致P-450系统含量和活性降低的部分原因可能是XO活性增加导致脂质过氧化增强。