Koizumi A, Walford R L, Imamura T
Biochem Biophys Res Commun. 1986 Jan 29;134(2):632-7. doi: 10.1016/s0006-291x(86)80466-1.
Treatment of mice and rats with polyriboinosinic acid-polyribocytidylic acid (poly I.C., 5 mg/kg i.p.), a potent interferon inducer, decreased hepatic cytochrome P-450 system content and activities without influencing P-450-independent xenobiotic metabolizing enzymes. Treatment with poly I.C. decreased the content of P-450 by 28% in mice (P less than 0.05) and 30% in rats (P less than 0.05) but did not alter the activity of cytochrome c reductase. With treatment of poly I.C., the activity of XO increased 87% in mice (P less than 0.01) and 30% in rats (P less than 0.01). Lipid peroxidation was enhanced by 82% in mice (P less than 0.01) and 95% in rats (P less than 0.05). These results raise the possibility that a part of the depression of P-450 system content and activities by poly I.C. might be caused by enhanced lipid peroxidation associated with increased activity of XO.
用聚肌苷酸-聚胞苷酸（聚肌胞苷酸，5毫克/千克腹腔注射）处理小鼠和大鼠，聚肌胞苷酸是一种强效干扰素诱导剂，它降低了肝脏细胞色素P-450系统的含量和活性，而不影响不依赖P-450的外源性物质代谢酶。用聚肌胞苷酸处理使小鼠体内P-450的含量降低了28%（P<0.05），大鼠降低了30%（P<0.05），但未改变细胞色素c还原酶的活性。用聚肌胞苷酸处理后，小鼠体内XO的活性增加了87%（P<0.01），大鼠增加了30%（P<0.01）。小鼠体内脂质过氧化增强了82%（P<0.01），大鼠增强了95%（P<0.05）。这些结果提示，聚肌胞苷酸导致P-450系统含量和活性降低的部分原因可能是XO活性增加导致脂质过氧化增强。
