Center of Excellence in Retina, Department of Ophthalmology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society.
Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Curr Opin Ophthalmol. 2023 Nov 1;34(6):522-528. doi: 10.1097/ICU.0000000000000988. Epub 2023 Aug 9.
This article reviewed and summarized recent published data on ocular imaging findings and treatment of posterior segment manifestations of ocular metastasis.
Advanced ocular imaging can help differentiate ocular metastases from other mimicking lesions, including primary intraocular tumors or infections. Recently, case reports have demonstrated the successful use of targeted systemic therapy to achieve local control of vitreous and choroidal metastases.
Metastasis can lead to a wide variety of posterior segment ocular manifestations. The choroid is the most common metastatic site, whereas tumor metastasizing to the retina and optic disc are rare. Patients with possible metastatic eye disease are recommended to undergo extensive investigation to determine the underlying primary cancer and ongoing systemic metastases. Currently, there is no consensus on the treatment strategy. Treatment generally includes systemic chemotherapy in combination with local treatment, such as radiotherapy, laser therapy, or anti-vascular endothelial growth factor (anti-VEGF) treatment.
本文回顾和总结了近期关于眼部转移瘤的后段表现的眼部影像学检查结果和治疗的研究数据。
先进的眼部影像学检查有助于将眼部转移瘤与其他类似病变区分开来，包括眼内原发肿瘤或感染。最近，病例报告表明，靶向全身治疗可成功实现玻璃体内和脉络膜转移瘤的局部控制。
转移瘤可导致多种后段眼部表现。脉络膜是最常见的转移部位，而转移至视网膜和视盘的肿瘤则较为罕见。对于疑似患有转移性眼病的患者，建议进行广泛的检查以确定潜在的原发性癌症和全身转移情况。目前，对于治疗策略尚无共识。治疗通常包括全身化疗联合局部治疗，如放疗、激光治疗或抗血管内皮生长因子（anti-VEGF）治疗。
