Deng Ling, Zheng Xiaoxia, Shuai Ping, Yu Xijie
Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.
Department of Health Management & Institute of Health Management, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Horm Metab Res. 2023 Oct;55(10):684-691. doi: 10.1055/a-2151-1538. Epub 2023 Aug 9.
The purpose of this study was to investigate the correlation of thyroid-related hormones changes within the reference range with the changes in anthropometric measures and incidence of obesity. The study included 4850 subjects with normal thyroid-related hormones at baseline and at follow-up. We evaluated the relationship of changes in thyroid-related biomarkers with anthropometric measures changes and incidence of obesity. In euthyroid persons, changes in serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) concentrations and FT3/FT4 ratio were independent predictors of changes in body mass index (BMI) and waist circumference (WC) in men, changes in serum FT3 and FT4 concentrations and FT3/FT4 ratio were independent predictors of changes in BMI and WC in women. Every single unit increment in ΔFT3/FT4 was accompanied by a 7.144 and 7.572 times risk of having obesity in men and women, respectively. Every single unit decrement in ΔFT4 was accompanied by a 21.0% and 26.9% lower risk of having obesity in men and women, respectively. In conclusion, in euthyroid individuals, changes in thyroid-related hormones were associated with anthropometric measures changes and incidence of obesity.
本研究的目的是调查甲状腺相关激素在参考范围内的变化与人体测量指标变化及肥胖发生率之间的相关性。该研究纳入了4850名在基线和随访时甲状腺相关激素正常的受试者。我们评估了甲状腺相关生物标志物的变化与人体测量指标变化及肥胖发生率之间的关系。在甲状腺功能正常的人群中，血清促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）浓度及FT3/FT4比值的变化是男性体重指数（BMI）和腰围（WC）变化的独立预测因素，血清FT3和FT4浓度及FT3/FT4比值的变化是女性BMI和WC变化的独立预测因素。男性和女性的ΔFT3/FT4每增加一个单位，肥胖风险分别增加7.144倍和7.572倍。男性和女性的ΔFT4每降低一个单位，肥胖风险分别降低21.0%和26.9%。总之，在甲状腺功能正常的个体中，甲状腺相关激素的变化与人体测量指标变化及肥胖发生率相关。
