Gandelman R, Graham S
Physiol Behav. 1986;37(3):465-7. doi: 10.1016/0031-9384(86)90207-6.
Eight-day pregnant mice were surgically prepared so that they carried a single fetus which was delivered by cesarean section on Day 18, one day prior to term. Other animals were permitted to carry their entire complement of fetuses which also were delivered surgically. Their position within a uterine horn relative to one another was noted. Adult ovariectomized testosterone-treated females that had been situated in utero contiguous to no male fetuses attacked an olfactory bulbectomized adult stimulus male. In contrast, females that resided singly in the uterus were unresponsive to the hormone; they displayed no aggressive behavior. Masculinization, therefore, appears to occur in utero in the absence of contiguity to male fetuses.
对怀孕8天的小鼠进行手术处理，使其怀有单个胎儿，并在妊娠期满前一天即第18天通过剖腹产分娩。其他动物则任其怀有全部胎儿，这些胎儿也通过手术分娩。记录了它们在子宫角内相对于彼此的位置。成年去卵巢并接受睾酮处理、在子宫内与雄性胎儿不相邻的雌性小鼠攻击了嗅球切除的成年雄性刺激物。相比之下，子宫内单独存在的雌性小鼠对该激素无反应；它们未表现出攻击行为。因此，雄性化似乎在子宫内发生，且无需与雄性胎儿相邻。
