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丙酸睾酮处理的雌性豚鼠子宫位置与雄性性行为激活

Uterine position and the activation of male sexual activity in testosterone propionate-treated female guinea pigs.

作者信息

Gandelman R

出版信息

Horm Behav. 1986 Sep;20(3):287-93. doi: 10.1016/0018-506x(86)90038-3.

DOI:10.1016/0018-506x(86)90038-3
PMID:3770652
Abstract

Fetal female guinea pigs were delivered surgically and their position within a uterine horn relative to male fetuses was noted. When adult they were ovariectomized, injected daily with testosterone propionate, and examined for male copulatory behaviors in response to the presence of a receptive female. Females that developed contiguous to a caudal male were functionally similar to those that had been situated between two males; both exhibited enhanced levels of mounting relative to females that were located contiguous to no males (with and without the presence of a caudal male) and to females contiguous to a cephalic male. Therefore, both contiguity and positioning of the male fetus are necessary conditions for prenatal masculinization of the female guinea pig. Lastly, four animals that had resided singly in the uterus displayed the lowest levels of copulatory behaviors.

摘要

通过手术取出雌性豚鼠胎儿,并记录其在子宫角内相对于雄性胎儿的位置。成年后,对它们进行卵巢切除,每天注射丙酸睾酮,并观察它们在有发情期雌鼠时的雄性交配行为。与尾侧雄性相邻发育的雌性在功能上与位于两个雄性之间的雌性相似;相对于没有与任何雄性相邻(无论有无尾侧雄性)以及与头侧雄性相邻的雌性,这两种情况下的雌性都表现出更高水平的骑跨行为。因此,雄性胎儿的相邻和位置对于雌性豚鼠的产前雄性化都是必要条件。最后,单独在子宫内的四只动物表现出最低水平的交配行为。

相似文献

1
Uterine position and the activation of male sexual activity in testosterone propionate-treated female guinea pigs.丙酸睾酮处理的雌性豚鼠子宫位置与雄性性行为激活
Horm Behav. 1986 Sep;20(3):287-93. doi: 10.1016/0018-506x(86)90038-3.
2
Singleton female mouse fetuses are subsequently unresponsive to the aggression-activating property of testosterone.单胎雌性小鼠胎儿随后对睾酮的攻击激活特性无反应。
Physiol Behav. 1986;37(3):465-7. doi: 10.1016/0031-9384(86)90207-6.
3
Neonatal testosterone administration, but not in utero contiguity to males, augments the display of male sexual behavior by testosterone-treated adult female mice.新生期给予睾酮,但并非在子宫内与雄性相邻,可增强经睾酮处理的成年雌性小鼠的雄性性行为表现。
Physiol Behav. 1988;42(5):453-6. doi: 10.1016/0031-9384(88)90175-8.
4
Fetal female rats are masculinized by male littermates located caudally in the uterus.子宫尾部的雄性同窝仔鼠会使雌性胎鼠雄性化。
Science. 1981 Jul 10;213(4504):239-42. doi: 10.1126/science.7244634.
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Masculinization and defeminization of female rats by males located caudally in the uterus.子宫尾部的雄性大鼠对雌性大鼠的雄性化和去雌性化作用。
Physiol Behav. 1990 Oct;48(4):555-60. doi: 10.1016/0031-9384(90)90299-j.
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Fetal effects on sexual behavior and aggression in young and old female mice treated with estrogen and testosterone.雌激素和睾酮处理的年轻及老年雌性小鼠中胎儿对性行为和攻击性的影响
Horm Behav. 1984 Jun;18(2):117-29. doi: 10.1016/0018-506x(84)90037-0.
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Effects of neonatal estrogen treatment of female guinea pigs on mounting behavior in adulthood.新生雌性豚鼠雌激素处理对成年后骑跨行为的影响。
Horm Behav. 1983 Sep;17(3):284-91. doi: 10.1016/0018-506x(83)90027-2.
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Effects of prenatal antiandrogen treatment on masculinization and defeminization of guinea pigs.
Physiol Behav. 1991 Sep;50(3):471-5. doi: 10.1016/0031-9384(91)90532-s.
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Effects of prenatal testosterone and ATD on reproductive behavior in guinea pigs.产前睾酮和芳香化酶抑制剂对豚鼠生殖行为的影响。
Physiol Behav. 1992 Jan;51(1):105-9. doi: 10.1016/0031-9384(92)90210-s.
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Further evidence for masculinization of female rats by males located caudally in utero.子宫内尾部位置的雄性使雌性大鼠雄性化的进一步证据。
Horm Behav. 1984 Dec;18(4):484-90. doi: 10.1016/0018-506x(84)90032-1.

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