Student Research Committee, Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran (the Islamic Republic of).
Student Research Committee, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran (the Islamic Republic of).
BMJ Open. 2023 Aug 9;13(8):e068626. doi: 10.1136/bmjopen-2022-068626.
Schizophrenia is a chronic, complex and severe psychiatric disorder affecting millions of people every year and inflicting different costs to the individual, family and community. A growing body of evidence has introduced several genetic and environmental factors and their interactions as aetiological factors of schizophrenia. The goal of this systematic review and meta-analysis is to present an updated representation of the global environmental risk factors of schizophrenia.
This protocol is developed and reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guideline. We will systematically search the databases such as PubMed, Scopus, Web of Science, PsycINFO and Embase until 30 September 2022. We include Cohort studies that have reported one or more risk factors of schizophrenia. We will also search Google Scholar search engine and references lists of included articles. Extracting the relevant data and assessing the quality of the included studies will be independently performed by different authors of our team. The risk of bias for the included studies will be evaluated using Newcastle-Ottawa Scale. Subgroup analysis, meta-regression or sensitivity analysis will be our solution to deal with heterogeneity between studies. We will use a funnel diagram as well as Begg and Egger tests to check for possible publication bias.
Ethical approval is not required because there will be no primary data collection or human involvement. The results of this study will be published in an international peer-reviewed journal.
CRD42022359327.
精神分裂症是一种慢性、复杂且严重的精神疾病，每年影响数百万人，并给个人、家庭和社区带来不同的成本。越来越多的证据表明，遗传和环境因素及其相互作用是精神分裂症的病因。本系统评价和荟萃分析的目的是呈现精神分裂症全球环境风险因素的最新综合描述。
本方案根据系统评价和荟萃分析报告的首选报告项目制定和报告。我们将系统地搜索数据库，如 PubMed、Scopus、Web of Science、PsycINFO 和 Embase，直到 2022 年 9 月 30 日。我们包括报告了一个或多个精神分裂症风险因素的队列研究。我们还将搜索 Google Scholar 搜索引擎和纳入文章的参考文献列表。我们团队的不同作者将独立提取相关数据并评估纳入研究的质量。将使用纽卡斯尔-渥太华量表评估纳入研究的偏倚风险。亚组分析、荟萃回归或敏感性分析将是我们处理研究间异质性的解决方案。我们将使用漏斗图以及 Begg 和 Egger 检验来检查可能存在的发表偏倚。
由于不会进行原始数据收集或涉及人类，因此不需要伦理批准。本研究的结果将发表在国际同行评议期刊上。
PROSPERO 注册号：CRD42022359327。
