Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kanagawa, Japan.
North Lab, Hokkaido, Japan.
J Vet Med Sci. 2023 Oct 17;85(10):1052-1056. doi: 10.1292/jvms.23-0136. Epub 2023 Aug 8.
An 11-year-old spayed female French bulldog was referred on suspicion of nasal tumor. Anaplastic oligodendroglioma in the olfactory bulb that was suspected to have invaded the nasal cavity was diagnosed from imaging and histopathology. Metastasis to cervical lymph nodes was suspected, with no other metastases identified. The brain-to-nasal lesion and lymph nodes were treated with hypo-fractionated radiation therapy. Nasal congestion soon resolved. About 3 months later, follow-up computed tomography revealed multiple hepatic and splenic masses, which were cytologically suspected as metastatic oligodendroglioma. Nimustine, followed by toceranib phosphate, seemed to have no effect, and the dog died on day 167. Postmortem examination revealed the primary tumor disappearance and systemic metastases. Canine oligodendroglioma can grow outside the cranial vault, and systemically metastasize.
一只 11 岁已去势的雌性法国斗牛犬因疑似鼻腔肿瘤而被转介。影像学和组织病理学检查怀疑嗅球的间变性少突胶质细胞瘤已侵犯鼻腔。怀疑发生颈部淋巴结转移，未发现其他转移灶。对脑部至鼻腔病变和淋巴结进行了低分割放射治疗。鼻塞很快得到缓解。大约 3 个月后，随访 CT 显示多个肝和脾肿块，细胞学怀疑为转移性少突胶质细胞瘤。尼莫司汀联合替莫唑胺治疗似乎没有效果，该犬在第 167 天死亡。尸检显示原发肿瘤消失和全身转移。犬的少突胶质细胞瘤可以在颅外生长，并发生全身转移。
