Leighty E G
Res Commun Chem Pathol Pharmacol. 1979 Mar;23(3):483-92.
We have previously identified long-retained metabolites of delta 9-tetrahydrocannabinol (delta 9-THC) and delta 8-tetrahydrocannabinol (delta 8-THC) in the rat as fatty acid conjugates of 11-hydroxy-delta 9-THC and 11-hydroxy-delta 8-THC. These metabolites can be produced in vitro using a rat liver microsomal energy-dependent esterase system.
我们之前已在大鼠体内鉴定出δ9-四氢大麻酚(δ9-THC)和δ8-四氢大麻酚(δ8-THC)的长时留存代谢物,它们是11-羟基-δ9-THC和11-羟基-δ8-THC的脂肪酸共轭物。这些代谢物可利用大鼠肝脏微粒体能量依赖性酯酶系统在体外产生。