Sickkids Hospital, Department of Pediatrics, Division Dermatology, University of Toronto, Canada.
J Cutan Med Surg. 2023 Sep-Oct;27(5):449-453. doi: 10.1177/12034754231191060. Epub 2023 Aug 9.
BACKGROUND/OBJECTIVES: Alopecia areata (AA) is a T-cell driven autoimmune disease, which results in hair loss. This study aims to determine the efficacy, tolerability and safety of different concentrations of anthralin in the treatment of pediatric AA.
A retrospective cohort study of patients < 18 yo diagnosed with AA treated with anthralin at SickKids Hospital, Toronto dermatology outpatient clinic in 2016 - 2018. Anthralin used at 0.1%, 0.2%, 0.5% and 1% in petrolatum at short contact, at increments of 15 minutes every week until a 1 hr maximum contact achieved. No other treatment was used in conjunction. Severity of Alopecia Tool (SALT) scores (SS) were determined using photographs and descriptions to assess severity of alopecia at baseline and post anthralin treatment.
A total of 11 charts were reviewed in this retrospective cohort. Hair loss pattern; 3 patients with patchy, 6 had mixed (patchy and ophiasis), and 2 were totalis. All except for 1 patient had failed traditional treatments. One patient had complete hair regrowth, 3 showed more than 85% hair re-growth and 7 patients showed more than 75% hair regrowth, the average time for this to occur was 6.5 months. None of the patients experience serious side effects.
Our study demonstrated the efficacy and tolerability of topical anthralin 0.1% to 1% in pediatric alopecia areata. In our study, anthralin 0.2% appears to offer the best performance and tolerability profile among the different concentrations used, with treatment course of at least 6 months in order to achieve more than 75% hair regrowth.
背景/目的：斑秃（AA）是一种由 T 细胞驱动的自身免疫性疾病，导致脱发。本研究旨在确定不同浓度蒽林治疗儿科 AA 的疗效、耐受性和安全性。
对 2016 年至 2018 年在多伦多皮肤科门诊和多伦多 SickKids 医院接受蒽林治疗的 <18 岁 AA 患者进行回顾性队列研究。蒽林在凡士林中使用 0.1%、0.2%、0.5%和 1%的浓度，短接触，每周增加 15 分钟，直到达到 1 小时的最大接触时间。没有使用其他治疗方法。使用照片和描述来确定脱发严重程度工具 (SALT) 评分 (SS)，以评估基线和蒽林治疗后脱发的严重程度。
本回顾性队列共回顾了 11 份图表。脱发模式；3 例斑片状，6 例混合性（斑片状和 ophiasis），2 例全秃。除 1 例患者外，所有患者均未接受传统治疗。1 例患者完全毛发再生，3 例患者毛发再生>85%，7 例患者毛发再生>75%，平均发生时间为 6.5 个月。没有患者出现严重的副作用。
我们的研究表明，0.1%至 1%的外用蒽林治疗儿科斑秃具有疗效和耐受性。在我们的研究中，0.2%的蒽林似乎在不同浓度中提供了最佳的疗效和耐受性，治疗过程至少 6 个月，以达到 75%以上的毛发再生。
