Conte C O, Rosito G B, Palmini A L, Lucion A B, De Almeida M A
Behav Brain Res. 1986 Aug;21(2):163-6. doi: 10.1016/0166-4328(86)90094-x.
The intracerebroventricular administration of 25 ng of Met-enkephalin causes retrograde amnesia for a shuttle avoidance task in intact rats. In demedullated rats, this effect of Met-enkephalin was lost. Intraperitoneal injection of 1.2 micrograms/kg adrenaline recovered the amnestic effect of Met-enkephalin. These results confirm the idea that the amnestic effect of Met-enkephalin is centrally mediated and that adrenal enkephalins do not seem to be important to the amnestic effect of Met-enkephalin since adrenaline recovers this effect in demedullated rats.
向完整大鼠脑室内注射25纳克甲硫氨酸脑啡肽会导致其在穿梭箱回避任务中出现逆行性遗忘。在去髓大鼠中，甲硫氨酸脑啡肽的这种作用消失了。腹腔注射1.2微克/千克肾上腺素可恢复甲硫氨酸脑啡肽的遗忘作用。这些结果证实了以下观点：甲硫氨酸脑啡肽的遗忘作用是由中枢介导的，并且肾上腺脑啡肽对甲硫氨酸脑啡肽的遗忘作用似乎并不重要，因为肾上腺素可在去髓大鼠中恢复这种作用。
