Farhat Maguy, Fuller Gregory N, Wintermark Max, Chung Caroline, Kumar Vinodh A, Chen Melissa
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Section of Neuropathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Neuroradiol J. 2023 Aug 10:19714009231193162. doi: 10.1177/19714009231193162.
Multifocal and multicentric glioblastoma (GBM) or collectively, m-GBM, is an imaging diagnosis present in up to 34% of patients with GBM. Compared to unifocal disease, patients with m-GBM have worse outcomes owing to the enhanced aggressive nature of the disease and its resistance to currently available treatments. To improve the understanding of its complex behavior, many associations have been established between the radiologic findings of m-GBM and its gross histology, genetic composition, and patterns of spread. Additionally, the holistic knowledge of the exact mechanisms of m-GBM genesis and progression is crucial for identifying potential targets permitting enhanced diagnosis and treatment. In this review, we aim to provide a comprehensive summary of the cumulative knowledge of the unique molecular biology and behavior of m-GBM and the association of these features with neuroimaging.
多灶性和多中心性胶质母细胞瘤（GBM），或统称为m-GBM，是一种影像学诊断，在高达34%的GBM患者中存在。与单灶性疾病相比，m-GBM患者的预后更差，这是由于该疾病具有更强的侵袭性及其对现有治疗的耐药性。为了更好地理解其复杂行为，人们已经在m-GBM的影像学表现与其大体组织学、基因组成和扩散模式之间建立了许多关联。此外，全面了解m-GBM发生和进展的确切机制对于确定能够改善诊断和治疗的潜在靶点至关重要。在本综述中，我们旨在全面总结关于m-GBM独特分子生物学和行为的累积知识，以及这些特征与神经影像学的关联。
