Ain Qurat Ul, Iqbal Muhammad Omer, Khan Imran Ahmad, Bano Naheed, Naeem Muhammad, Jamaludin Mohamad Ikhwan, Devaraj Sutha
Ali-Ul-Murtaza, Department of Rehabilitation Sciences, Muhammad Institute of Medical and Allied Sciences Multan 60000, Punjab, Pakistan.
Department of Pathobiology, MNS University of Agriculture Multan 60000, Punjab, Pakistan.
Am J Transl Res. 2023 Jul 15;15(7):4533-4543. eCollection 2023.
Plant-based natural antioxidants have a wide variety of biological activities with significant therapeutic value. has been used traditionally to treat a variety of ailments in animals and human, but little is defined about its biological or pharmacological effects. Therefore, the objective of the present study was to evaluate phytochemical, antioxidant, antipyretic and anti-inflammatory activities of aqueous-methanolic leaf extract of .
To investigate the possible impact of aqueous-methanolic leaf extract of on oxidative stress, inflammation, and pyrexia, we used a combined in vitro and in vivo series of experiments on laboratory animals.
Results revealed significant antioxidant potential in 2,2-diphenylpicrylhydrazyl (DPPH) and nitric oxide (NO) scavenging assay, while significant but dose dependent antipyretic potential was documented in typhoid-paratyphoid A and B (TAB) vaccine and prostaglandin E (PGE) induced pyrexia models. Significant anti-inflammatory effects were observed in both acute and chronic inflammatory models of arachidonic acid and formalin. Phytochemical screening and high-performance liquid chromatography (HPLC) analysis of confirmed the presence of mangiferin, quercetin, and isoquercetin. These phytoconstituents likely play a role in the observed biological activities. Our results show that has antioxidant, anti-inflammatory, and antipyretic effects, lending credence to its traditional use and advocating for its utilization as a viable contender in treating oxidative stress-associated ailments.
It is concluded that has various properties in the treatment of various diseases.
植物源天然抗氧化剂具有多种生物活性，具有重要的治疗价值。传统上已被用于治疗动物和人类的多种疾病，但其生物学或药理作用鲜为人知。因此，本研究的目的是评估[植物名称]水-甲醇叶提取物的植物化学、抗氧化、解热和抗炎活性。
为了研究[植物名称]水-甲醇叶提取物对氧化应激、炎症和发热的可能影响，我们在实验动物上进行了一系列体外和体内联合实验。
结果显示在2,2-二苯基苦味酰基肼（DPPH）和一氧化氮（NO）清除试验中具有显著的抗氧化潜力，而在伤寒-副伤寒甲乙（TAB）疫苗和前列腺素E（PGE）诱导的发热模型中记录到显著但剂量依赖性的解热潜力。在花生四烯酸和福尔马林的急性和慢性炎症模型中均观察到显著的抗炎作用。[植物名称]的植物化学筛选和高效液相色谱（HPLC）分析证实了芒果苷、槲皮素和异槲皮素的存在。这些植物成分可能在观察到的生物活性中发挥作用。我们的结果表明[植物名称]具有抗氧化、抗炎和解热作用，这为其传统用途提供了依据，并主张将其作为治疗氧化应激相关疾病的可行候选药物加以利用。
得出结论，[植物名称]在治疗各种疾病方面具有多种特性。
