Wei Lu, Zhang Jialin, Di Dake, Wang Dongmei, Luo Guangpu
Department of Traditional Chinese Medicine Dermatology, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Aug 4;16:2021-2028. doi: 10.2147/CCID.S418750. eCollection 2023.
Cutaneous plasmacytosis (CP) is a rare disorder of uncertain etiology. We report an unusual and rare case of CP in a 57‑year‑old male who presented with popular nodules all over the body, accompanied by head plaques. Pathological biopsy of the skin revealed large infiltration of mature plasma cells within the dermis. Elevated serum IgG4 concentrations were found. Immunohistochemical analysis confirmed the polyclonal nature of the plasma cells. The diagnosis of CP was established. Steroid therapy was administered at a dose of 20 mg/day. After 1 month of treatment, the patient's eruption showed regression. These findings remind dermatologists to include CP in their clinical differential diagnosis of patients with head plaques. Meanwhile, clinicians should carefully that individuals diagnosed with CP at risk for malignant transformation.
皮肤浆细胞增多症（CP）是一种病因不明的罕见疾病。我们报告了一例罕见的不寻常CP病例，患者为一名57岁男性，全身出现丘疹性结节，并伴有头部斑块。皮肤病理活检显示真皮内有大量成熟浆细胞浸润。血清IgG4浓度升高。免疫组化分析证实浆细胞为多克隆性。CP诊断成立。给予患者20mg/天的类固醇治疗。治疗1个月后，患者皮疹消退。这些发现提醒皮肤科医生在对有头部斑块的患者进行临床鉴别诊断时应考虑CP。同时，临床医生应谨慎注意，诊断为CP的个体有恶变风险。
