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Aflatoxin B1 exposure triggers hepatic lipotoxicity via p53 and perilipin 2 interaction-mediated mitochondria-lipid droplet contacts: An in vitro and in vivo assessment.黄曲霉毒素 B1 暴露通过 p53 和 perilipin 2 相互作用介导的线粒体-脂滴接触引发肝脂肪毒性：一项体外和体内评估。
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Rab7a-mTORC1 signaling-mediated cholesterol trafficking from the lysosome to mitochondria ameliorates hepatic lipotoxicity induced by aflatoxin B1 exposure.Rab7a-雷帕霉素复合物1信号介导的胆固醇从溶酶体到线粒体的转运改善了黄曲霉毒素B1暴露诱导的肝脏脂毒性。
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[Lipid peroxides and some aspects of their biological action].
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本文引用的文献

1
Therapeutic vs. Suprapharmacological Metformin Concentrations: Different Effects on Energy Metabolism and Mitochondrial Function in Skeletal Muscle Cells .治疗性与超药理剂量二甲双胍浓度：对骨骼肌细胞能量代谢和线粒体功能的不同影响
Front Pharmacol. 2022 Jul 6;13:930308. doi: 10.3389/fphar.2022.930308. eCollection 2022.
2
In vitro models of insulin resistance: Mitochondrial coupling is differently affected in liver and muscle cells.胰岛素抵抗的体外模型：线粒体偶联在肝脏和肌肉细胞中的影响不同。
Mitochondrion. 2021 Nov;61:165-173. doi: 10.1016/j.mito.2021.10.001. Epub 2021 Oct 8.
3
Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism.长链酰基辅酶 A 通过 PTP1B 依赖机制降低胰岛素受体 Tyr1151 的磷酸化。
Int J Mol Sci. 2021 Jun 16;22(12):6470. doi: 10.3390/ijms22126470.
4
Targeting Mitochondria in Diabetes.靶向糖尿病中的线粒体。
Int J Mol Sci. 2021 Jun 21;22(12):6642. doi: 10.3390/ijms22126642.
5
Diet-induced obese mouse hearts tolerate an acute high-fatty acid exposure that also increases ischemic tolerance.饮食诱导肥胖的老鼠心脏能耐受急性高脂肪酸暴露，也能增加对缺血的耐受性。
Am J Physiol Heart Circ Physiol. 2020 Sep 1;319(3):H682-H693. doi: 10.1152/ajpheart.00284.2020. Epub 2020 Aug 14.
6
Altered mitochondrial metabolism in the insulin-resistant heart.胰岛素抵抗心脏中线粒体代谢的改变。
Acta Physiol (Oxf). 2020 Mar;228(3):e13430. doi: 10.1111/apha.13430. Epub 2019 Dec 30.
7
Dietary Calanus oil recovers metabolic flexibility and rescues postischemic cardiac function in obese female mice.饮食中海生桡足类油可恢复肥胖雌性小鼠的代谢灵活性并挽救其缺血后心脏功能。
Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H290-H299. doi: 10.1152/ajpheart.00191.2019. Epub 2019 May 24.
8
Acute and long-term administration of palmitoylcarnitine induces muscle-specific insulin resistance in mice.棕榈酰肉碱的急性和长期给药可诱导小鼠肌肉特异性胰岛素抵抗。
Biofactors. 2017 Sep 10;43(5):718-730. doi: 10.1002/biof.1378. Epub 2017 Jul 31.
9
DAG tales: the multiple faces of diacylglycerol--stereochemistry, metabolism, and signaling.二酰甘油的故事：二酰甘油的多面性——立体化学、代谢及信号传导
Cell Mol Life Sci. 2015 Oct;72(20):3931-52. doi: 10.1007/s00018-015-1982-3. Epub 2015 Jul 8.
10
Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism.己酮可可碱可降低非酒精性脂肪性肝炎中的氧化脂质产物：潜在治疗机制的新证据。
Hepatology. 2012 Oct;56(4):1291-9. doi: 10.1002/hep.25778.

Editorial: Lipotoxicity, mitotoxicity, and drug targets.

作者信息

Krako Jakovljevic Nina, Boardman Neoma T, Makrecka-Kuka Marina

机构信息

Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, Faculty of Medicine University of Belgrade, Belgrade, Serbia.

Department Medical Biology, Faculty of Health Sciences, UiT-Arctic University of Norway, Tromsø, Norway.

出版信息

Front Endocrinol (Lausanne). 2023 Jul 25;14:1245111. doi: 10.3389/fendo.2023.1245111. eCollection 2023.

DOI:10.3389/fendo.2023.1245111
PMID:37560301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10408128/
Abstract
摘要