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美泊利单抗治疗合并感染的变应性支气管肺曲霉病

Mepolizumab in allergic bronchopulmonary aspergillosis complicated by infection.

作者信息

Hamada Toru, Katsuta Tomoya, Aibara Kento, Nozu Shohei, Nakamura Junya, Kondo Haruka, Tachibana Sayaka, Inoue Koji, Nakanishi Norihiko, Moritaka Tomonori

机构信息

Respiratory Medicine, Ehime Prefectural Central Hospital, Matsuyama, Ehime, 790-0024, Japan.

出版信息

Respir Med Case Rep. 2023 Jul 16;45:101890. doi: 10.1016/j.rmcr.2023.101890. eCollection 2023.

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is an allergic reaction caused by the fungus , and it is often treated with steroids or antifungal agents. However, long-term use of these medications can lead to infections and drug interactions. We present the case of a 71-year-old woman with ABPA who was diagnosed with hepatitis B and active hepatitis C, and sputum analysis revealed the presence of bacteria. Oral steroids were initially administered, but the patient was switched to mepolizumab because of numerous infectious complications. The early introduction of mepolizumab is effective in patients with ABPA complicated by infectious diseases.

摘要

变应性支气管肺曲霉病(ABPA)是一种由真菌引起的过敏反应,通常用类固醇或抗真菌药物治疗。然而,长期使用这些药物会导致感染和药物相互作用。我们报告一例71岁患有ABPA的女性病例,该患者被诊断为乙型肝炎和丙型肝炎活动期,痰分析显示存在细菌。最初给予口服类固醇治疗,但由于出现大量感染并发症,该患者改用美泊利单抗治疗。早期使用美泊利单抗对合并感染性疾病的ABPA患者有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ae/10407267/37ba99c09df5/gr1.jpg

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