Korovljev Darinka, Ostojic Jelena, Todorovic Nikola, Ostojic Sergej M
FSPE Applied Bioenergetics Lab, University of Novi Sad, Novi Sad, Serbia.
Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Arch Med Sci. 2023 Jul 13;19(4):1151-1153. doi: 10.5114/aoms/162938. eCollection 2023.
We evaluated whether 12-week intake of molecular hydrogen (H) in 5 overweight adults (3 women; age: 50.2 ±11.9 years, body mass index: 29.4 ±2.1 kg/m) affects brain levels of the glutamate-glutamine-GABA cycle, critical amino acid neurotransmitters in the mechanism of neuronal activation during appetite regulation.
A 1.5-T single-voxel proton magnetic resonance spectroscopy was used to assess the tissue concentrations of relevant metabolites.
The mean glutamate and glutamate-plus-glutamine levels at the posterior cingulate gyrus decreased significantly during the study; this was accompanied by a significant drop in GABA levels at left prefrontal white matter, and glutathione levels at anterior cingulate gyrus. No changes in the brain metabolites were found in the comparable group of overweight individuals ( = 4, 2 women; age: 41.0 ±13.9, BMI 26.8 ±1.3 kg/m) followed-up in the past without this treatment.
We showed a possible hydrogen-driven upregulation of neurotransmitters involved in appetite stimulation leading to hunger suppression and weight loss. Further studies analyzing appetite-controlling metabolic pathways affected by H would require monitoring of additional biomarkers of satiation and satiety during different feeding regimens.
我们评估了5名超重成年人（3名女性；年龄：50.2±11.9岁，体重指数：29.4±2.1kg/m²）摄入分子氢（H₂）12周是否会影响谷氨酸-谷氨酰胺-γ-氨基丁酸循环的脑内水平，这是食欲调节过程中神经元激活机制中的关键氨基酸神经递质。
使用1.5-T单像素质子磁共振波谱来评估相关代谢物的组织浓度。
在研究期间，后扣带回的平均谷氨酸和谷氨酸加谷氨酰胺水平显著下降；同时，左侧前额叶白质的γ-氨基丁酸水平以及前扣带回的谷胱甘肽水平也显著下降。在过去未接受此治疗的超重个体对照组（n = 4，2名女性；年龄：41.0±13.9，BMI 26.8±1.3kg/m²）中，未发现脑代谢物有变化。
我们发现分子氢可能上调参与食欲刺激的神经递质，从而导致饥饿抑制和体重减轻。进一步分析受分子氢影响的食欲控制代谢途径的研究，需要在不同饮食方案期间监测饱腹感和满足感的其他生物标志物。
