乳腺癌患者的血浆脂质与催乳素
Plasma lipids and prolactin in patients with breast cancer.
作者信息
Bani I A, Williams C M, Boulter P S, Dickerson J W
出版信息
Br J Cancer. 1986 Sep;54(3):439-46. doi: 10.1038/bjc.1986.195.
Abstract
In a comparative study of pre- and postmenopausal women with benign and malignant breast disease, a number of differences were observed in circulating plasma prolactin and lipid concentrations. Plasma lipids, phospholipids, triglycerides, cholesterol and free fatty acids were all higher in blood obtained from breast cancer patients prior to surgery. HDL-Cholesterol levels were significantly lower in these patients. These differences remained when the patient groups were sub-divided according to menopausal status. Plasma prolactin concentrations were also found to be higher in cancer compared with non-cancer patients, this effect being more marked in premenopausal than in postmenopausal patients. Premenopausal patients with invasive or poorly differentiated disease had significantly higher prolactin levels than those with non-invasive disease. No correlations were found between plasma prolactin and any of the lipid fractions.
摘要
在一项针对绝经前和绝经后患有良性和恶性乳腺疾病女性的对比研究中，观察到循环血浆催乳素和脂质浓度存在一些差异。乳腺癌患者术前血液中的血浆脂质、磷脂、甘油三酯、胆固醇和游离脂肪酸均较高。这些患者的高密度脂蛋白胆固醇水平显著较低。当根据绝经状态对患者组进行细分时，这些差异依然存在。与非癌症患者相比，癌症患者的血浆催乳素浓度也更高，这种影响在绝经前患者中比绝经后患者更为明显。患有浸润性或低分化疾病的绝经前患者的催乳素水平明显高于非浸润性疾病患者。未发现血浆催乳素与任何脂质成分之间存在相关性。
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