Chan P C, Dao T L
Cancer Res. 1981 Jan;41(1):164-7.
The relationship between dietary fat and mammary carcinogenesis was examined by feeding a high-fat or a low-fat purified diet, differing only in fat and carbohydrate content, to Fischer, Long-Evans, and Sprague-Dawley rats. An additional group of rats from each strain was fed a nonpurified laboratory diet for comparison. The rats were given an i.v. dose of N-nitrosomethylurea (50 mg/kg body weight) at 50 days of age. The results showed that (a) a high-fat purified diet significantly enhanced mammary carcinogenesis; (b) a nonpurified laboratory diet retarded mammary carcinogenesis compared to a low-fat purified diet; (c) rats on three different diets had a similar body weight gain; (d) the susceptibility of N-nitrosomethylurea-induced mammary carcinogenesis in the three strains of rats was in the order of Sprague-Dawley > Fischer > Long-Evans; and (e) Fischer rats appeared to be better suited for further systematic studies of dietary fat and mammary carcinogenesis.
通过给Fischer、Long-Evans和Sprague-Dawley大鼠喂食仅脂肪和碳水化合物含量不同的高脂或低脂纯化饮食，研究了膳食脂肪与乳腺癌发生之间的关系。每组大鼠中额外有一组喂食非纯化的实验室饮食作为对照。在50日龄时给大鼠静脉注射N-亚硝基甲脲（50毫克/千克体重）。结果表明：（a）高脂纯化饮食显著增强乳腺癌发生；（b）与低脂纯化饮食相比，非纯化实验室饮食延缓乳腺癌发生；（c）三种不同饮食的大鼠体重增加相似；（d）三种品系大鼠对N-亚硝基甲脲诱导的乳腺癌发生的易感性顺序为Sprague-Dawley＞Fischer＞Long-Evans；（e）Fischer大鼠似乎更适合进一步系统研究膳食脂肪与乳腺癌发生。
