Baumbach Andreas, Patel Kush P, Kennon Simon, Ozkor Mick, Mathur Anthony, Huerta Frank de la, Tamm Alexander R
Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, UK.
Barts Heart Centre, St Bartholomew's Hospital, London, UK.
Catheter Cardiovasc Interv. 2023 Oct;102(4):766-771. doi: 10.1002/ccd.30795. Epub 2023 Aug 10.
Aortic regurgitation (AR) is associated with morbidity and premature mortality. Surgical aortic valve replacement is not an option for many patients due to an adverse surgical risk profile, whilst transcatheter aortic valve implantation with most available prostheses has demonstrated suboptimal implantation success and outcomes. The JenaValve Trilogy™ system provides an attractive solution for such patients as it utilizes clips that directly attach onto the native valve leaflets to anchor. Initially designed for transapical delivery, the current transfemoral delivery system is under investigation in the United States and approved for aortic stenosis and regurgitation in Europe. We present an expert review on the technical aspects of the Trilogy system, provide a guide for implantation, discuss the available evidence for the technology and provide illustrative case examples.
主动脉瓣反流（AR）与发病率和过早死亡率相关。由于手术风险不利，手术主动脉瓣置换术对许多患者来说并非选择，而使用大多数现有假体进行经导管主动脉瓣植入术已显示出植入成功率和效果欠佳。耶拿瓣膜三部曲™系统为这类患者提供了一个有吸引力的解决方案，因为它使用直接附着在天然瓣膜小叶上的夹子来固定。该系统最初设计用于经心尖输送，目前的经股动脉输送系统正在美国进行研究，并在欧洲被批准用于主动脉瓣狭窄和反流。我们对三部曲系统的技术方面进行了专家综述，提供了植入指南，讨论了该技术的现有证据，并提供了说明性病例示例。
