Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom.
Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
EuroIntervention. 2024 Sep 2;20(17):e1062-e1075. doi: 10.4244/EIJ-D-23-00840.
Aortic regurgitation (AR) is a common clinical disease associated with significant morbidity and mortality. Investigations based largely on non-invasive imaging are pivotal in discerning the severity of disease and its impact on the heart. Advances in technology have contributed to improved risk stratification and to our understanding of the pathophysiology of AR. Surgical aortic valve replacement is the predominant treatment. However, its use is limited to patients with an acceptable surgical risk profile. Transcatheter aortic valve implantation is an alternative treatment. However, this therapy remains in its infancy, and further data and experience are required. This review article on AR describes its prevalence, mechanisms, diagnosis and treatment.
主动脉瓣反流（AR）是一种常见的临床疾病，与较高的发病率和死亡率相关。主要基于非侵入性影像学的检查对于明确疾病的严重程度及其对心脏的影响至关重要。技术的进步有助于改善风险分层，并增进我们对 AR 病理生理学的理解。外科主动脉瓣置换术是主要的治疗方法。但是，其使用仅限于具有可接受手术风险特征的患者。经导管主动脉瓣植入术是一种替代治疗方法。但是，这种治疗仍处于起步阶段，需要更多的数据和经验。本文对 AR 的流行情况、发病机制、诊断和治疗进行了综述。
