Clin Lab. 2023 Aug 1;69(8). doi: 10.7754/Clin.Lab.2023.221019.
The aim was to investigate circ-HMGCS1 expression and its correlation with clinical features and survival in cervical cancer (CC) patients.
This prospective study recruited 100 patients with CC who underwent surgical resection. Circ-HMGCS1 expression was measured by RT-qPCR. Disease-free survival (DFS) and overall survival (OS) were recorded.
Circ-HMGCS1 was upregulated in tumor tissues and had a good value in separating tumor tissues from normal tissues. Circ-HMGCS1 expression in tumor tissues was positively correlated with tumor size, lymph node metastasis, and FIGO stage. High circ-HMGCS1 expression predicted worse DFS and OS.
circ-HMGCS1 serves as an indicator of survival and prognosis in CC patients.
本研究旨在探讨环状 RNA（circ-HMGCS1）在宫颈癌（CC）患者中的表达及其与临床特征和生存的相关性。
本前瞻性研究纳入了 100 例接受手术切除的 CC 患者。采用 RT-qPCR 检测 circ-HMGCS1 的表达。记录无病生存（DFS）和总生存（OS）。
circ-HMGCS1 在肿瘤组织中上调，并且在区分肿瘤组织和正常组织方面具有良好的价值。肿瘤组织中 circ-HMGCS1 的表达与肿瘤大小、淋巴结转移和 FIGO 分期呈正相关。高 circ-HMGCS1 表达预示着较差的 DFS 和 OS。
circ-HMGCS1 可作为 CC 患者生存和预后的指标。
