Clin Lab. 2023 Aug 1;69(8). doi: 10.7754/Clin.Lab.2023.220826.
This study aimed to investigate the value of miR-671-5p in multiple myeloma (MM) in diagnostics and prognosis and developed a potential biomarker to improve the prognosis of MM.
Plasma cells were isolated from bone marrow samples of 80 MM patients, in which miR-671-5p levels were determined. The correlation between miR-671-5p expression with serum creatinine, β-2-microglobulin, lactate dehydrogenase, bone lesions, International Staging System staging, chromosomal abnormalities, and albumin was analyzed. The association between miR-671-5p expression with progression-free survival and overall survival in MM patients was determined.
miR-671-5p expression was reduced and predicted an increased risk of MM. miR-671-5p expression was negatively correlated with serum creatinine, β-2-microglobulin, lactate dehydrogenase, bone lesions, International Staging System staging, and chromosomal abnormalities, and positively correlated with albumin. miR-671-5p expression was augmented in complete response patients and overall response rate patients, and differentiated CR and ORR patients from Non-CR and Non-ORR patients. Furthermore, miR-671-5p low expression was associated with unfavorable progression-free survival and overall survival in MM patients.
In a word, miR-671-5p is associated with worsening clinical properties, increased ISS staging, unfavorable chromosomal abnormalities, and poor prognosis in MM patients.
本研究旨在探讨微小 RNA-671-5p（miR-671-5p）在多发性骨髓瘤（MM）中的诊断和预后价值，并开发一种潜在的生物标志物以改善 MM 的预后。
从 80 例 MM 患者的骨髓样本中分离浆细胞，测定 miR-671-5p 水平。分析 miR-671-5p 表达与血清肌酐、β2-微球蛋白、乳酸脱氢酶、骨病变、国际分期系统（ISS）分期、染色体异常和白蛋白之间的相关性。分析 miR-671-5p 表达与 MM 患者无进展生存和总生存的关系。
miR-671-5p 表达降低，提示 MM 风险增加。miR-671-5p 表达与血清肌酐、β2-微球蛋白、乳酸脱氢酶、骨病变、ISS 分期和染色体异常呈负相关，与白蛋白呈正相关。在完全缓解（CR）患者和总缓解率（ORR）患者中，miR-671-5p 表达增加，并将 CR 和 ORR 患者与非 CR 和非 ORR 患者区分开来。此外，miR-671-5p 低表达与 MM 患者无进展生存和总生存不良相关。
总之，miR-671-5p 与 MM 患者临床特征恶化、ISS 分期增加、染色体异常不良和预后不良相关。
