Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.
National Skin Centre, Singapore, Singapore.
J Biophotonics. 2023 Dec;16(12):e202300191. doi: 10.1002/jbio.202300191. Epub 2023 Sep 17.
A handheld non-invasive confocal Raman system (CRS) was used to evaluate the differences in skin biochemicals between atopic dermatitis (AD) and psoriasis, which are inflammatory skin conditions. Raman spectral measurements in the fingerprint and high wavenumber region were acquired using a portable in-house CRS system with excitation lasers operating at 671 and 785 nm. It was deduced that relative amount of water decreases in the following sequence of skin: healthy, psoriasis and AD. Moreover, differential trends were observed for the subclasses of ceramides such that ceramide 3 is lower in the lesional AD and psoriasis skin as compared to healthy, while ceramide 2 showed a contrasting trend of decrease in lesional AD and increase in lesional psoriasis as opposed to healthy skin. Amount of cholesterol was significantly higher in lesional psoriasis as compared to lesional AD and healthy skin. These differences can aid in an objective classification of the skin conditions and in the formulation of new disease-specific topical treatments.
一种手持式非侵入式共焦拉曼系统（CRS）被用于评估特应性皮炎（AD）和银屑病这两种炎症性皮肤病之间的皮肤生化差异。使用便携式内部 CRS 系统在指纹和高波数区域获得拉曼光谱测量，其激发激光分别在 671nm 和 785nm 下运行。推断出皮肤中水分的相对含量按以下顺序减少：健康、银屑病和 AD。此外，还观察到神经酰胺亚类的差异趋势，即病变 AD 和银屑病皮肤中的神经酰胺 3 低于健康皮肤，而神经酰胺 2 在病变 AD 中呈下降趋势，在病变银屑病中呈上升趋势，与健康皮肤相反。病变银屑病中的胆固醇含量明显高于病变 AD 和健康皮肤。这些差异有助于对皮肤状况进行客观分类，并制定新的针对特定疾病的局部治疗方法。
