Department of Psychology & Biobehavioral Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Department of Psychology, The University of Mississippi, University Park, Mississippi, USA.
Pediatr Blood Cancer. 2023 Nov;70(11):e30621. doi: 10.1002/pbc.30621. Epub 2023 Aug 10.
Pain and fatigue are among the most common and impactful complications of sickle cell disease (SCD). Individuals with SCD are also more likely to have neurocognitive deficits. Previous studies have suggested that pain and fatigue might influence neurocognitive functioning in patients with SCD. However, these studies are limited by small sample sizes and inadequate measurement of cognitive performance. The present study aimed to investigate the relationship between pain and fatigue with neurocognitive functioning using performance-based measures of neurocognition. Pain and fatigue were not associated with neurocognitive performance. Implications and directions for future research are discussed.
疼痛和疲劳是镰状细胞病（SCD）最常见和最具影响力的并发症之一。患有 SCD 的人也更有可能出现神经认知缺陷。先前的研究表明，疼痛和疲劳可能会影响 SCD 患者的神经认知功能。然而，这些研究受到样本量小和认知表现测量不足的限制。本研究旨在使用神经认知的基于表现的测量方法来研究疼痛和疲劳与神经认知功能之间的关系。疼痛和疲劳与神经认知表现无关。讨论了对未来研究的影响和方向。
