Pediatr Ann. 2023 Aug;52(8):e297-e302. doi: 10.3928/19382359-20230613-04. Epub 2023 Aug 1.
Cholestasis affects 2% of newborns admitted to the neonatal intensive care unit and 20% of premature infants and requires a thoughtful evaluation and diagnostic workup.There may be a single responsible etiology, or its development may be multifactorial. Premature neonates are especially predisposed because of their increased risk of infections and acute illness, need for parenteral nutrition, and exposure to certain medications. Clinically, an infant may present with jaundice, evidence of hepatic injury, or worsening hepatic function. Diagnosis may be made in consultation with various pediatric subspecialists including gastroenterology, genetics, and surgery. Treatment depends on the etiology but may include medications or surgical interventions. Timely recognition and intervention improve outcomes. .
胆汁淤积症影响了 2%新生儿重症监护病房的新生儿和 20%的早产儿，需要进行深思熟虑的评估和诊断。其可能存在单一的致病因素，也可能是多因素的。早产儿特别容易患上胆汁淤积症，因为他们有更高的感染和急性疾病风险，需要肠外营养，以及接触某些药物。临床上，婴儿可能出现黄疸、肝损伤的证据或肝功能恶化。诊断可能需要咨询儿科各个亚专科医生，包括消化科、遗传学和外科。治疗取决于病因，但可能包括药物治疗或手术干预。及时识别和干预可以改善预后。
