School of Nursing, Peking University, Beijing, China.
Department of Organ Transplantation Center, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China.
J Psychosom Res. 2023 Oct;173:111443. doi: 10.1016/j.jpsychores.2023.111443. Epub 2023 Aug 5.
This study aimed to systematically review the prevalence and factors associated with depression and anxiety in living liver donors after liver transplantation.
Five English language electronic databases and four Chinese language electronic databases were searched from inception to February 2023. Two investigators independently extracted the data and assessed the study quality. The pooled prevalence was calculated using STATA software (version 14.0). We performed a narrative review to summarize the factors associated with depression and anxiety in living liver donors after liver transplantation. The protocol of this study was registered with the International Prospective Register of Systematic Reviews (PROSPERO) database, registration number: CRD42021290071.
This study included 39 articles involving 18,577 participants. The pooled prevalence was 6.3% [95% confidence interval (CI) (4.1-8.9%)] for depression in living liver donors, and 10.0% [95% CI (4.0-18.1%)] for anxiety. Prevalence of clinically significant depressive or anxiety symptoms was higher (15.7% and 17.4%) compared with disorders (2.7% and 2.2%). The prevalence of depression and anxiety was highest within 3 months post-donation. Specifically, female donors, serious postoperative complications, and recipients' poor health/death have been reported as factors having a negative influence on depression and anxiety.
Collected evidence showed that the overall prevalence of depression or anxiety of living liver donors was high. Therefore, early detection and timely treatment of psychological disorders are crucial to promote positive psychiatric health outcomes and ensure the quality of life of living liver donors.
本研究旨在系统综述肝移植后活体肝供者抑郁和焦虑的患病率及相关因素。
检索了从建库至 2023 年 2 月的 5 个英文电子数据库和 4 个中文电子数据库。由 2 名研究者独立提取数据并评价研究质量。使用 STATA 软件（版本 14.0）计算汇总患病率。我们采用叙述性综述来总结肝移植后活体肝供者抑郁和焦虑的相关因素。本研究方案已在国际前瞻性系统评价注册库（PROSPERO）注册，注册号：CRD42021290071。
本研究共纳入 39 篇文章，涉及 18577 名参与者。肝移植后活体肝供者抑郁的汇总患病率为 6.3%（95%可信区间[CI]：4.1%8.9%），焦虑的患病率为 10.0%（95% CI：4.0%18.1%）。与障碍相比，有临床意义的抑郁或焦虑症状的患病率更高（15.7%和 17.4%）。供者术后 3 个月内抑郁和焦虑的患病率最高。具体而言，女性供者、严重术后并发症以及受者健康状况不佳/死亡被报道为对抑郁和焦虑产生负面影响的因素。
现有证据表明，活体肝供者抑郁或焦虑的总体患病率较高。因此，早期发现和及时治疗心理障碍对于促进心理健康结局和确保活体肝供者的生活质量至关重要。
