Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7FZ, UK.
Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, NDM Research Building, Roosevelt Drive, Oxford, OX3 7FZ, UK.
Curr Opin Struct Biol. 2023 Oct;82:102665. doi: 10.1016/j.sbi.2023.102665. Epub 2023 Aug 8.
The past few years have seen exciting discoveries in the area of tyrosine kinase structural biology including the first high resolution models of full-length receptor tyrosine kinases and new mechanistic insights into the structural mechanisms of receptor tyrosine kinase activation. Despite being a mature area of research, the application of new technologies continues to advance our understanding. In this article we highlight a selection of recent studies that illustrate the current areas of research interest, focussing in particular on the exciting progress made possible by cryo-electron-microscopy. These new discoveries may herald a wave of new design ideas for therapeutics acting through novel mechanisms.
过去几年，酪氨酸激酶结构生物学领域取得了令人兴奋的发现，包括首个全长受体酪氨酸激酶的高分辨率模型和受体酪氨酸激酶激活的结构机制的新机制见解。尽管这是一个成熟的研究领域，但新技术的应用仍在不断推动我们的理解。本文重点介绍了一些最近的研究，这些研究说明了当前的研究兴趣领域，特别是通过低温电子显微镜取得的令人兴奋的进展。这些新发现可能预示着通过新机制发挥作用的治疗药物的新设计理念的浪潮。
