University of Southwest Petroleum University, College of Mechanical and Electrical Engineering, Chengdu, China.
University of Electronic Science and Technology of China, Chengdu, China.
Talanta. 2024 Jan 1;266(Pt 1):124996. doi: 10.1016/j.talanta.2023.124996. Epub 2023 Jul 26.
With the rapid development of clinical pharmacy in China, therapeutic drug monitoring (TDM) has become an essential tool for guiding rational clinical drug use and is widely concerned. TDM is a tool that combines pharmacokinetic and pharmacodynamic knowledge to optimize personalized drug therapy, which can improve treatment outcomes, reduce drug-drug toxicity, and avoid the risk of developing drug resistance. To effectively implement TDM, accurate and sophisticated analytical methods are required. By researching the literature published in recent years, we summarize the types of commonly monitored drugs, therapeutic windows, and clinical assays and track the trends and hot spots of therapeutic drug monitoring. The purpose is to provide guidelines for clinical blood drug concentration monitoring, to implement individualized drug delivery programs better, to ensure the rational use of drugs for patients, and to provide a reference for the group to carry out related topics in the future.
随着临床药学在中国的快速发展，治疗药物监测（TDM）已成为指导合理临床用药的重要工具，受到广泛关注。TDM 是一种将药代动力学和药效学知识相结合的工具，用于优化个体化药物治疗，可改善治疗效果、降低药物毒性、避免耐药风险。为了有效地实施 TDM，需要准确和复杂的分析方法。通过研究近年来发表的文献，我们总结了常用监测药物的类型、治疗窗和临床检测方法，并跟踪治疗药物监测的趋势和热点。目的是为临床血药浓度监测提供指导，更好地实施个体化药物输送方案，确保患者合理用药，并为该团队未来开展相关课题提供参考。
