Song Zidong, Shi Meng, Ren Xiaopeng, Wang Luyang, Wu Yili, Fan Yujie, Zhang Yinping, Xu Ying
Department of Building Science, Tsinghua University, Beijing, China; Beijing Key Laboratory of Indoor Air Quality Evaluation and Control, Beijing, China.
Department of Building Science, Tsinghua University, Beijing, China; Beijing Key Laboratory of Indoor Air Quality Evaluation and Control, Beijing, China; Department of Civil, Architectural and Environmental Engineering, The University of Texas at Austin, TX, USA.
J Hazard Mater. 2023 Oct 5;459:132202. doi: 10.1016/j.jhazmat.2023.132202. Epub 2023 Aug 2.
Household dust contains a wide variety of semi-volatile organic compounds (SVOCs) that may pose health risks. We developed a method integrating non-targeted analysis (NTA) and targeted analysis (TA) to identify SVOCs in indoor dust. Based on a combined use of gas and liquid chromatography with high-resolution mass spectrometry, an automated, time-efficient NTA workflow was developed, and high accuracy was observed. A total of 128 compounds were identified at confidence level 1 or 2 in NIST standard reference material dust (SRM 2585). Among them, 113 compounds had not been reported previously, and this suggested the value of NTA in characterizing contaminants in dust. Additionally, TA was done to avoid the loss of trace compounds. By integrating data obtained from the NTA and TA approaches, SVOCs in SRM 2585 were prioritized based on exposure and chemical toxicity. Six of the top 20 compounds have never been reported in SRM 2585, including melamine, dinonyl phthalate, oxybenzone, diheptyl phthalate, drometrizole, and 2-phenylphenol. Additionally, significant influences of analytical instruments and sample preparation on NTA results were observed. Overall, the developed method provided a powerful tool for identifying SVOCs in indoor dust, which is necessary to obtain a more complete understanding of chemical exposures and risks in indoor environments.
室内灰尘含有多种可能对健康构成风险的半挥发性有机化合物（SVOCs）。我们开发了一种将非靶向分析（NTA）和靶向分析（TA）相结合的方法，用于识别室内灰尘中的SVOCs。基于气相色谱和液相色谱与高分辨率质谱联用，开发了一种自动化、省时的NTA工作流程，并观察到了高精度。在NIST标准参考物质灰尘（SRM 2585）中，在置信水平1或2下共鉴定出128种化合物。其中，有113种化合物此前未被报道，这表明NTA在表征灰尘中的污染物方面具有价值。此外，进行了靶向分析以避免痕量化合物的损失。通过整合从NTA和TA方法获得的数据，根据暴露情况和化学毒性对SRM 2585中的SVOCs进行了优先级排序。排名前20的化合物中有6种在SRM 2585中从未被报道过，包括三聚氰胺、邻苯二甲酸二壬酯、二苯甲酰甲烷、邻苯二甲酸二庚酯、甲酚曲唑三硅氧烷和2-苯基苯酚。此外，还观察到分析仪器和样品制备对NTA结果有显著影响。总体而言，所开发的方法为识别室内灰尘中的SVOCs提供了一个强大的工具，这对于更全面地了解室内环境中的化学暴露和风险是必要的。
