• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

健康和神经紊乱状态下颅骨骨髓的独特分子特征。

Distinct molecular profiles of skull bone marrow in health and neurological disorders.

机构信息

Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute for Stroke and Dementia Research, LMU University Hospital, Ludwig-Maximilians University Munich, Munich, Germany; Graduate School of Systemic Neurosciences (GSN), Munich, Germany.

Institute for Tissue Engineering and Regenerative Medicine (iTERM), Helmholtz Center, Neuherberg, Munich, Germany; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

出版信息

Cell. 2023 Aug 17;186(17):3706-3725.e29. doi: 10.1016/j.cell.2023.07.009. Epub 2023 Aug 9.

DOI:10.1016/j.cell.2023.07.009
PMID:37562402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10443631/
Abstract

The bone marrow in the skull is important for shaping immune responses in the brain and meninges, but its molecular makeup among bones and relevance in human diseases remain unclear. Here, we show that the mouse skull has the most distinct transcriptomic profile compared with other bones in states of health and injury, characterized by a late-stage neutrophil phenotype. In humans, proteome analysis reveals that the skull marrow is the most distinct, with differentially expressed neutrophil-related pathways and a unique synaptic protein signature. 3D imaging demonstrates the structural and cellular details of human skull-meninges connections (SMCs) compared with veins. Last, using translocator protein positron emission tomography (TSPO-PET) imaging, we show that the skull bone marrow reflects inflammatory brain responses with a disease-specific spatial distribution in patients with various neurological disorders. The unique molecular profile and anatomical and functional connections of the skull show its potential as a site for diagnosing, monitoring, and treating brain diseases.

摘要

颅骨中的骨髓对于大脑和脑膜中的免疫反应形成非常重要，但它在骨骼中的分子组成及其在人类疾病中的相关性尚不清楚。在这里，我们表明，与健康和受伤状态下的其他骨骼相比，老鼠颅骨具有最独特的转录组特征，其特征是晚期中性粒细胞表型。在人类中，蛋白质组分析表明，颅骨骨髓是最独特的，具有不同表达的中性粒细胞相关途径和独特的突触蛋白特征。3D 成像显示了与静脉相比，人类颅骨-脑膜连接 (SMC) 的结构和细胞细节。最后，使用转位蛋白正电子发射断层扫描 (TSPO-PET) 成像，我们表明，颅骨骨髓反映了炎症性大脑反应，在患有各种神经疾病的患者中具有特定疾病的空间分布。颅骨独特的分子特征以及解剖和功能连接表明其具有作为诊断、监测和治疗脑部疾病的部位的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/62b9bde752a0/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/f77fef150ad2/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/c3e185b3251c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/a48b89b1985d/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/bdc71f3129ee/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/787eb4671d8d/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/4642ca3dc89e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/ddc8741d7df3/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/a6485947dec9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/3a8453700b88/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/46eb947d123d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/e2ca4abe3a00/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/13471593fbac/figs6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/84fec1c3bf83/figs7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/ca3d93b20d0e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/62b9bde752a0/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/f77fef150ad2/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/c3e185b3251c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/a48b89b1985d/figs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/bdc71f3129ee/figs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/787eb4671d8d/figs3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/4642ca3dc89e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/ddc8741d7df3/figs4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/a6485947dec9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/3a8453700b88/figs5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/46eb947d123d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/e2ca4abe3a00/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/13471593fbac/figs6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/84fec1c3bf83/figs7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/ca3d93b20d0e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5cb/10443631/62b9bde752a0/gr7.jpg

相似文献

1
Distinct molecular profiles of skull bone marrow in health and neurological disorders.健康和神经紊乱状态下颅骨骨髓的独特分子特征。
Cell. 2023 Aug 17;186(17):3706-3725.e29. doi: 10.1016/j.cell.2023.07.009. Epub 2023 Aug 9.
2
Quantitative assessment of translocator protein (TSPO) in the non-human primate brain and clinical translation of [F]LW223 as a TSPO-targeted PET radioligand.非人灵长类动物大脑中转运体蛋白（TSPO）的定量评估以及[F]LW223作为TSPO靶向正电子发射断层显像（PET）放射性配体的临床转化
Pharmacol Res. 2023 Mar;189:106681. doi: 10.1016/j.phrs.2023.106681. Epub 2023 Feb 4.
3
Acetamidobenzoxazolone scaffold as a promising translocator protein (18 kDa, TSPO) marker for neuroinflammation imaging: Advancement in last decennial period.乙酰氨基苯并恶唑酮支架作为一种用于神经炎症成像的有前景的转位蛋白（18 kDa，TSPO）标记物：过去十年的进展。
Drug Dev Res. 2022 Nov;83(7):1519-1533. doi: 10.1002/ddr.21989. Epub 2022 Sep 8.
4
Neuroinflammation PET imaging of the translocator protein (TSPO) in Alzheimer's disease: An update.阿尔茨海默病中转位蛋白（TSPO）的神经炎症 PET 成像：最新进展。
Eur J Neurosci. 2022 Mar;55(5):1322-1343. doi: 10.1111/ejn.15613. Epub 2022 Feb 10.
5
[F]CB251 PET/MR imaging probe targeting translocator protein (TSPO) independent of its Polymorphism in a Neuroinflammation Model.[F]CB251 正电子发射断层扫描/磁共振成像探针，针对神经炎症模型中 TSPO 多态性的非依赖性。
Theranostics. 2020 Jul 23;10(20):9315-9331. doi: 10.7150/thno.46875. eCollection 2020.
6
Neuroinflammation in Neurodegenerative Disorders-a Review.神经退行性疾病中的神经炎症——综述。
Curr Neurol Neurosci Rep. 2017 Mar;17(3):25. doi: 10.1007/s11910-017-0733-2.
7
In vivo evaluation of a novel F-labeled PET radioligand for translocator protein 18 kDa (TSPO) in monkey brain.在体评价新型 F 标记的 18 kDa 膜转位蛋白（TSPO）正电子发射断层扫描（PET）放射性配体在猴脑中的应用。
Eur J Nucl Med Mol Imaging. 2023 Aug;50(10):2962-2970. doi: 10.1007/s00259-023-06270-9. Epub 2023 May 30.
8
Positron Emission Tomography studies with [11C]PBR28 in the Healthy Rodent Brain: Validating SUV as an Outcome Measure of Neuroinflammation.[11C]PBR28 在健康啮齿动物大脑中的正电子发射断层扫描研究：验证标准化摄取值作为神经炎症的结果指标
PLoS One. 2015 May 21;10(5):e0125917. doi: 10.1371/journal.pone.0125917. eCollection 2015.
9
Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study.大麻素受体 2 的上调，而非 TSPO，在小鼠加速衰老的神经炎症中：一项正电子发射断层扫描研究。
J Neuroinflammation. 2019 Nov 10;16(1):208. doi: 10.1186/s12974-019-1604-3.
10
Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization.用 TSPO 成像神经炎症：细胞来源和亚细胞定位的新视角。
Pharmacol Ther. 2022 Jun;234:108048. doi: 10.1016/j.pharmthera.2021.108048. Epub 2021 Nov 27.

引用本文的文献

1
Cranial glucose metabolic patterns across prodromal and clinical parkinson's disease revealed by F-FDG PET.F-FDG PET 揭示前驱期和临床期帕金森病的颅葡萄糖代谢模式。
Eur J Nucl Med Mol Imaging. 2025 Sep 3. doi: 10.1007/s00259-025-07533-3.
2
Chronic social defeat stress induces meningeal neutrophilia via type I interferon signaling in male mice.慢性社会挫败应激通过I型干扰素信号通路诱导雄性小鼠脑膜嗜中性粒细胞增多。
Nat Commun. 2025 Sep 1;16(1):8153. doi: 10.1038/s41467-025-62840-5.
3
Neutrophil Heterogeneity in Airway Inflammatory Diseases.

本文引用的文献

1
Deciphering sources of PET signals in the tumor microenvironment of glioblastoma at cellular resolution.解析胶质母细胞瘤肿瘤微环境中细胞分辨率下的 PET 信号来源。
Sci Adv. 2023 Oct 27;9(43):eadi8986. doi: 10.1126/sciadv.adi8986.
2
Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies.原发性和转发性 tau 病患者中 Aβ-、tau-和神经退行性变（ATN）与小胶质细胞激活的个体区域关联。
Mol Psychiatry. 2023 Oct;28(10):4438-4450. doi: 10.1038/s41380-023-02188-8. Epub 2023 Jul 26.
3
PyWGCNA: a Python package for weighted gene co-expression network analysis.
气道炎性疾病中的中性粒细胞异质性
Inflammation. 2025 Aug 19. doi: 10.1007/s10753-025-02351-z.
4
Advances in Collateral Neuroimaging for Acute Ischemic Stroke: Redefining Time and Tissue Windows in the Reperfusion Era.急性缺血性卒中侧支神经影像学进展：在再灌注时代重新定义时间和组织窗
J Neuroimaging. 2025 Jul-Aug;35(4):e70079. doi: 10.1111/jon.70079.
5
Contemporary insights into neuroimmune interactions across development and aging.对发育和衰老过程中神经免疫相互作用的当代见解。
Front Neurol. 2025 Jul 25;16:1611124. doi: 10.3389/fneur.2025.1611124. eCollection 2025.
6
Single-Cell Approaches Define the Murine Leptomeninges: Cortical Brain Interface as a Distinct Cellular Neighborhood Composed of Neural and Non-neural Cell Types.单细胞方法定义了小鼠软脑膜：皮质脑界面是一个由神经和非神经细胞类型组成的独特细胞邻域。
eNeuro. 2025 Aug 22;12(8). doi: 10.1523/ENEURO.0046-25.2025. Print 2025 Aug.
7
Adaptive immunity in the neuroinflammation of Alzheimer's disease.阿尔茨海默病神经炎症中的适应性免疫。
Chin Med J (Engl). 2025 Sep 5;138(17):2116-2129. doi: 10.1097/CM9.0000000000003695. Epub 2025 Aug 5.
8
Editorial: Community series in trends in neuroimmunology: cross-talk between brain-resident and peripheral immune cells in both health and disease, volume II.社论：神经免疫学趋势中的社区系列：健康与疾病状态下脑内固有免疫细胞与外周免疫细胞之间的相互作用，第二卷
Front Immunol. 2025 Jul 3;16:1644278. doi: 10.3389/fimmu.2025.1644278. eCollection 2025.
9
[Advances in the Study of Calvarial Stem Cells].[颅骨干细胞研究进展]
Sichuan Da Xue Xue Bao Yi Xue Ban. 2025 Mar 20;56(2):584-590. doi: 10.12182/20250360609.
10
Perineural immune environment of olfactory nerves is reshaped by neuroinflammatory drainage and connects to ethmoid bone marrow.嗅神经的神经周围免疫环境通过神经炎性引流重塑，并与筛窦骨髓相连。
Sci Adv. 2025 Jun 27;11(26):eadt9591. doi: 10.1126/sciadv.adt9591. Epub 2025 Jun 25.
PyWGCNA：用于加权基因共表达网络分析的 Python 包。
Bioinformatics. 2023 Jul 1;39(7). doi: 10.1093/bioinformatics/btad415.
4
The extracellular matrix and the immune system: A mutually dependent relationship.细胞外基质与免疫系统：相互依存的关系。
Science. 2023 Feb 17;379(6633):eabp8964. doi: 10.1126/science.abp8964.
5
Whole-mouse clearing and imaging at the cellular level with vDISCO.利用 vDISCO 进行全鼠细胞水平的透明化和成像。
Nat Protoc. 2023 Apr;18(4):1197-1242. doi: 10.1038/s41596-022-00788-2. Epub 2023 Jan 25.
6
Spatial proteomics in three-dimensional intact specimens.三维完整标本中的空间蛋白质组学。
Cell. 2022 Dec 22;185(26):5040-5058.e19. doi: 10.1016/j.cell.2022.11.021.
7
Brain borders at the central stage of neuroimmunology.神经免疫学术研究的核心：脑区边界
Nature. 2022 Dec;612(7940):417-429. doi: 10.1038/s41586-022-05474-7. Epub 2022 Dec 14.
8
Arachnoid granulations are lymphatic conduits that communicate with bone marrow and dura-arachnoid stroma.蛛网膜粒是与骨髓和硬脑膜-蛛网膜基质相通的淋巴管通道。
J Exp Med. 2023 Feb 6;220(2). doi: 10.1084/jem.20220618. Epub 2022 Dec 5.
9
Proteomic Analysis of Murine Bone Marrow Very Small Embryonic-like Stem Cells at Steady-State Conditions and after In Vivo Stimulation by Nicotinamide and Follicle-Stimulating Factor Reflects their Germ-Lineage Origin and Multi Germ Layer Differentiation Potential.在稳态条件下和体内受烟酰胺和卵泡刺激素刺激后，对鼠骨髓极小胚胎样干细胞的蛋白质组学分析反映了它们的生殖系起源和多胚层分化潜能。
Stem Cell Rev Rep. 2023 Jan;19(1):120-132. doi: 10.1007/s12015-022-10445-6. Epub 2022 Aug 20.
10
Emerging role of anti-proliferative protein BTG1 and BTG2.抗增殖蛋白 BTG1 和 BTG2 的新作用。
BMB Rep. 2022 Aug;55(8):380-388. doi: 10.5483/BMBRep.2022.55.8.092.