[Demonstration and characteristics of the perinucleolar zone of the nucleus--a new morphological criterion of the nucleolar test system].

A dynamic structure of interphase nucleus--perinucleolar zone has been detected and studied in cell systems on high-level transcription and proliferation activity by means of light and fluorescent microscopy methods. A new light-microscopic level classification of nucleoli taking into account the structure of this zone is introduced. The percentage of nucleoli type distribution may be used as criterion of tissue synthesis activity. An introduction of a new morphological criterion in classical Smetana nucleolar test is under discussion.