Levitsky L L, Paton J B, Fisher D E
Biol Neonate. 1986;50(2):97-106. doi: 10.1159/000242574.
Gluconeogenesis from lactate may be qualitatively identified in the chronically catheterized baboon fetus in the maternal fed and fasted state. Infusion of 250 microCi U-14C-lactate to the fetus over a 150-min period leads to the appearance of 14C-glucose in the fetal circulation. Little 14C-lactate or glucose appears in the maternal circulation, supporting fetal production of glucose from lactate. Maternal glucose infusion seems to inhibit fetal gluconeogenesis. The mean plateau in percent disintegrations per minute of glucose compared to lactate in the maternal fed state is 14.7 +/- 2.2 compared to 16.1 +/- 3.0 in the maternal fasting state and 11.1 +/- 0.6 during maternal glucose infusion. It is clear that the primate fetus is capable of gluconeogenesis before term. Quantitation of this capacity awaits development of a model permitting assessment of maternal-placental and fetal substrate flux.
在长期插管的狒狒胎儿处于母体进食和禁食状态时，可定性鉴定出由乳酸生成葡萄糖的糖异生作用。在150分钟内给胎儿输注250微居里的U-14C-乳酸，会导致胎儿循环中出现14C-葡萄糖。母体循环中几乎没有14C-乳酸或葡萄糖出现，这支持了胎儿由乳酸生成葡萄糖。母体输注葡萄糖似乎会抑制胎儿的糖异生作用。在母体进食状态下，葡萄糖每分钟衰变百分比相对于乳酸的平均稳定水平为14.7±2.2，而在母体禁食状态下为16.1±3.0，在母体输注葡萄糖期间为11.1±0.6。显然，灵长类胎儿在足月前就具备糖异生能力。这种能力的定量分析有待开发出一种模型，以便评估母体-胎盘和胎儿底物通量。
