Bond T C, Rothschild A J, Lerbinger J, Schatzberg A F
Biol Psychiatry. 1986 Nov;21(13):1239-46. doi: 10.1016/0006-3223(86)90306-9.
Results of the Dexamethasone Suppression Test (DST), performed on 65 patients with major unipolar depression, were classified both by suppression versus nonsuppression and by three ranges of postdexamethasone cortisol levels. Subgroups of patients were then compared for familial prevalence for depression and alcoholism and for delusional symptomatology. A strong association emerged among high postdexamethasone cortisol levels, a significantly increased familial prevalence for depression, and the presence of delusions in probands. In this study, ranges of DST responses were superior to suppression versus nonsuppression criteria alone in defining this subgroup.
对65例重度单相抑郁症患者进行了地塞米松抑制试验（DST），结果根据抑制与否以及地塞米松给药后皮质醇水平的三个范围进行分类。然后比较各亚组患者抑郁症和酒精中毒的家族患病率以及妄想症状。地塞米松给药后皮质醇水平高、抑郁症家族患病率显著增加以及先证者存在妄想之间出现了强烈关联。在本研究中，DST反应范围在定义该亚组方面优于单独的抑制与非抑制标准。
