Rudorfer M V, Hwu H G, Clayton P J
Biol Psychiatry. 1982 Jan;17(1):41-8.
The overnight dexamethasone suppression test (DST) was administered to 31 inpatients with endogenous depression. DST results were abnormal in 42% of the group and in 67% of those patients with psychotic depression. Division of the sample into genetic subtypes based on family history criteria of Winokur et al. failed to replicate his group's DST findings. Subjects with sporadic depressive disorder, especially delusional patients, had a higher rate of dexamethasone nonsuppression than the others. Familial pure depressive patients did not show the expected greater frequency of DST abnormality compared to the depression spectrum disorder group.
对31名内因性抑郁症住院患者进行了夜间地塞米松抑制试验（DST）。该组中42%的患者DST结果异常，而在伴有精神病性症状的抑郁症患者中这一比例为67%。根据维诺克等人的家族史标准将样本分为遗传亚型，未能重现其团队的DST研究结果。散发性抑郁症患者，尤其是妄想症患者，地塞米松不抑制率高于其他患者。与抑郁谱系障碍组相比，家族性单纯抑郁症患者并未表现出预期中更高的DST异常发生率。
